Publication Name	World Journal of Gastroenterology
Manuscript ID	12747
Country	China

Received	2014-07-24 19:04
Peer-Review Started	2014-07-25 15:33
To Make the First Decision	2014-08-27 19:17
Return for Revision	2014-09-03 18:50
Revised	2014-09-22 23:40
Second Decision	2014-12-02 07:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-16 10:08
Articles in Press	2014-12-16 10:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-01-08 12:41
Typeset the Manuscript	2015-02-08 16:53
Publish the Manuscript Online	2015-02-28 17:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Succinate dehydrogenase-deficient gastrointestinal stromal tumors
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Mei Wang, Meng-Li Gu and Feng Ji
Funding Agency and Grant Number
Corresponding Author	Feng Ji, MD, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qing Chun Road, Hangzhou 310003, Zhejiang Province, China. wym910319@126.com
Key Words	Gastrointestinal stromal tumors; Succinate dehydrogenase; Insulin-like growth factor 1 receptor; Vascular endothelial growth factor receptor; Hypoxia-inducible factor 1a
Core Tip	Succinate dehydrogenase (SDH) deficiency occurs in about 5%-7.5% of gastrointestinal stromal tumors (GISTs). These so-called SDH-deficient GISTs lack KIT and PDGFRA mutations. Such type of GISTs has its own clinical, morphological and molecular characteristics. The accumulation of hypoxia-inducible factor 1? and the upregulation of its downstream molecules, such as insulin-like growth factor 1 and vascular endothelial growth factor receptor, may play important roles in the tumorigenesis of SDH-deficient GISTs. They are promising to be the novel therapeutic targets of GISTs.
Publish Date	2015-02-28 17:07
Citation	Wang YM, Gu ML, Ji F. Succinate dehydrogenase-deficient gastrointestinal stromal tumors. World J Gastroenterol 2015; 21(8): 2303-2314
URL	http://www.wjgnet.com/1007-9327/full/v21/i8/2303.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i8.2303

Full Article (PDF)	WJG-21-2303.pdf
Full Article (Word)	WJG-21-2303.doc
Manuscript File	12747-Review.doc
Answering Reviewers	12747-Answering reviewers.pdf
Copyright License Agreement	12747-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12747-Language certificate.pdf
Peer-review Report	12747-Peer review(s).pdf
Scientific Misconduct Check	12747-CrossCheck.jpg
Scientific Editor Work List	12747-Scientific editor work list.pdf