Publication Name	World Journal of Diabetes
Manuscript ID	12750
Country	Japan

Received	2014-07-24 18:57
Peer-Review Started	2014-07-25 21:19
First Decision by Editorial Office Director
Return for Revision	2014-08-17 12:38
Revised	2014-08-21 14:08
Publication Fee Transferred
Second Decision by Editor	2014-10-27 16:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-10-27 17:12
Articles in Press	2014-10-27 17:12
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-27 17:00
Publish the Manuscript Online	2014-12-13 19:01

ISSN	1948-9358 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Possible contribution of (pro)renin receptor to development of gestational diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Kanako Bokuda and Atsuhiro Ichihara
Funding Agency and Grant Number
Corresponding Author	Kanako Bokuda, MD, Department of Medicine Ⅱ, Institute of Endocrinology and Hypertension, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. mkanakom31@yahoo.co.jp
Key Words	(Pro)renin receptor; Gestational diabetes mellitus; Embryonic growth; Renin-angiotensin system; Vacuolar H+-ATPase; Wnt signaling
Core Tip	Prorenin receptor [(P)RR] binds (pro)renin, and leads to the activation of tissue renin-angiotensin system and intracellular signalings. It also plays an important role as vacuolar H+-ATPase associated protein, involving in Wnt signaling. Elevated plasma soluble (P)RR [s(P)RR] levels in the early stage of pregnancies are associated with higher incidence of gestational diabetes mellitus (GDM) during the third trimester. Also, elevated s(P)RR levels in cord blood, associated with a lower small for gestational age birth likelihood, suggesting the involvement of (P)RR in embryo’s growth. Here we attempt to elucidate the possible pathophysiological roles of the (P)RR in GDM.
Publish Date	2014-12-13 19:01
Citation	Bokuda K, Ichihara A. Possible contribution of (pro)renin receptor to development of gestational diabetes mellitus. World J Diabetes 2014; 5(6): 912-916
URL	http://www.wjgnet.com/1948-9358/full/v5/i6/912.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i6.912

Full Article (PDF)	WJD-5-912.pdf
Full Article (Word)	WJD-5-912.doc
Manuscript File	12750-Review.docx
Answering Reviewers	12750-Answering reviewers.pdf
Copyright License Agreement	12750-Copyright assignment.pdf
Peer-review Report	12750-Peer review(s).pdf
Scientific Misconduct Check	12750-CrossCheck.jpg
Scientific Editor Work List	12750-Scientific editor work list.pdf