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Publication Name World Journal of Clinical Cases
Manuscript ID 127546
Country India
Received
2026-09-01 03:41
Peer-Review Started
2026-09-01 03:42
First Decision by Editorial Office Director
Return for Revision
2026-09-23 07:21
Revised
2026-10-04 05:38
Publication Fee Transferred
Second Decision by Editor
2026-10-20 07:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-10-20 09:37
Articles in Press
2026-10-20 09:37
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-10-21 02:58
Publish the Manuscript Online
2026-10-23 08:55
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Esophageal stricture due to amyloidosis in plasma cell dyscrasia: A case report and review of literature
Manuscript Source Invited Manuscript
All Author List Sanjeev Sachdeva, Nikhil Sirohi, koushik mandal, Dhruv Bansal, Venkatesh Vaithiyam, Ashok Dalal, Surbhi Goyal and Puja Sakhuja
ORCID
Author(s) ORCID Number
Sanjeev Sachdeva http://orcid.org/0000-0002-5588-1111
Venkatesh Vaithiyam http://orcid.org/0000-0002-0713-5501
Funding Agency and Grant Number
Corresponding Author Venkatesh Vaithiyam, Consultant, DM, MD, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, 80 Feet Road, Lake View Road, Deputy Collector Colony, New Delhi 110002, Delhi, India. venkateshvaithiyam172@gmail.com
Key Words Amyloidosis; Dysphagia; Esophageal stricture; Plasma cell dyscrasia; Balloon dilatation; Congo red staining; Case report
Core Tip Esophageal involvement in systemic amyloidosis is rare and presents in variable ways. We report a 65-year-old woman with progressive dysphagia, weight loss, and an upper esophageal stricture. Biopsy demonstrated Congo red-positive amyloid with lambda light-chain restriction, and bone marrow examination revealed approximately 50% lambda-restricted plasma cells, establishing an underlying plasma-cell dyscrasia. Although fat-pad and rectal biopsies were negative, a direct esophageal biopsy confirmed amyloid deposition at the site of disease. Endoscopic balloon dilation resulted in complete resolution of dysphagia, and daratumumab, bortezomib, cyclophosphamide, and dexamethasone therapy was initiated for disease modification.
Publish Date 2026-10-23 08:55
Citation

Sachdeva S, Sirohi N, mandal K, Bansal D, Vaithiyam V, Dalal A, Goyal S, Sakhuja P. Esophageal stricture due to amyloidosis in plasma cell dyscrasia: A case report and review of literature. World J Clin Cases 2026; 17(28): 127546

URL https://www.wjgnet.com/2307-8960/full/v14/i28/127546.htm
DOI https://doi.org/10.12998/wjcc.127546
Full Article (PDF) WJCC-14-127546-with-cover.pdf
CARE Checklist–2016 127546-CARE-Checklist-2016.pdf
Manuscript File 127546_Auto_Edited_011942.docx
Answering Reviewers 127546-answering-reviewers.pdf
Audio Core Tip 127546-audio.wav
Conflict-of-Interest Disclosure Form 127546-conflict-of-interest-statement.pdf
Copyright License Agreement 127546-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 127546-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 127546-non-native-speakers.pdf
Peer-review Report 127546-peer-reviews.pdf
Scientific Misconduct Check 127546-scientific-misconduct-check.png
CrossCheck Report 127546-crosscheck-report.pdf