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Articles Published Processes
9/28/2014 2:57:00 PM | Browse: 1080 | Download: 1073
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Received |
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2014-07-25 08:44 |
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Peer-Review Started |
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2014-07-25 09:18 |
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To Make the First Decision |
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2014-08-14 14:55 |
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Return for Revision |
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2014-08-14 20:08 |
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Revised |
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2014-08-24 11:44 |
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Second Decision |
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2014-09-01 15:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-01 15:23 |
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Articles in Press |
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2014-09-01 15:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-09-16 19:25 |
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Typeset the Manuscript |
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2014-09-22 17:35 |
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Publish the Manuscript Online |
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2014-09-28 14:56 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of liver stem cells in hepatocarcinogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lei-Bo Xu and Chao Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Research Foundation of the National Natural Science Foundation of China |
81172068 |
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| Corresponding Author |
Chao Liu, MD, PhD, Department of Hepato-pancreato-biliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan Jiang Xi Lu, Guangzhou 510120, Guangdong Province, China. mdliuchao@hotmail.com |
| Key Words |
Liver cancer; Liver stem cells; Hepatocarcinogenesis; Tumorigenic transformation; Transdifferentiation |
| Core Tip |
Liver cancer is an aggressive disease with a high mortality rate. However, the concept of liver cancer origin is controversial. Recently, there is increasing evidence for the “cancer stem cell hypothesis”, which proposes that liver cancer originates from the malignant transformation of liver stem/progenitor cells (liver cancer stem cells). This cancer stem cell model has important significance for understanding the basic biology of liver cancer and has profound importance for the development of new strategies for cancer prevention and treatment. This review discusses current knowledge concerning the role of liver stem cells in the hepatocarcinogenesis of primary liver cancer. |
| Publish Date |
2014-09-28 14:56 |
| Citation |
Xu LB, Liu C. Role of liver stem cells in hepatocarcinogenesis. World J Stem Cells 2014; 6(5): 579-590 |
| URL |
http://www.wjgnet.com/1948-0210/full/v6/i5/579.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v6.i5.579 |
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