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5/30/2015 1:35:00 PM | Browse: 605 | Download: 560
Publication Name World Journal of Gastroenterology
Manuscript ID 12776
Country of Manuscript Source United States
Received
2014-07-25 18:05
Peer-Review Started
2014-07-26 13:39
To Make the First Decision
2014-09-27 15:18
Return for Revision
2014-10-11 14:56
Revised
2014-11-10 03:11
Second Decision
2014-12-16 15:29
Accepted by Journal Editor-in-Chief
2014-12-17 03:19
Accepted by Company Editor-in-Chief
2014-12-22 17:04
Articles in Press
2014-12-22 17:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-05-15 19:36
Publish the Manuscript Online
2015-05-30 13:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model
Manuscript Source Unsolicited Manuscript
All Author List Linda S Gutierrez, Jun Ling, Derek Nye, Konstantina Papathomas and Catherine Dickinson
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health R15 DK067901-02
Howard Hughes Medical Institute 52006328
Wilkes Mentoring funds and institutional funds from Wilkes University and TCMC
Corresponding author Linda S Gutierrez, MD, Department of Biology and Health Sciences, Wilkes University, 230 Cohen Science Center, 84 West South Street, Wilkes-Barre, PA 18766, United States. linda.gutierrez@wilkes.edu
Keywords Thrombospondin 1; ABT-898; ABT-510; Angiogenesis; Inflammatory bowel disease; Dextran sodium sulfate model; Interleukin-6; STAT-3
Core Tip Inflammatory bowel disease is still incurable and a major burden in the patient’s life and health care system. The discovery of new and safe therapeutic alternatives is urgently needed. This study tested the efficacy of a new thrombospondin- derived peptide, ABT-898 in a murine model of colitis. Our results indicate that this peptide was able to ameliorate inflammation and angiogenesis. In addition, mice treated with ABT-898 showed significant decrease of plasmatic Interleukin-6 and lesser activation of signal transducer and activator of transcription 3 in colitic lesions. These findings suggest that ABT-898 may indeed be an alternative treatment for inflammatory bowel disease.
Publish Date 2015-05-30 13:32
Citation Gutierrez LS, Ling J, Nye D, Papathomas K, Dickinson C. Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model. World J Gastroenterol 2015; 21(20): 6157-6166
Url http://www.wjgnet.com/1007-9327/full/v21/i20/6157.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i20.6157
Full Article (PDF) WJG-21-6157.pdf
Full Article (Word) WJG-21-6157.doc
Manuscript File 12776-Review.doc
Answering Reviewers 12776-Answering reviewers.pdf
Copyright License Agreement 12776-Copyright assignment.pdf
Peer-review Report 12776-Peer review(s).pdf
Scientific Misconduct Check 12776-CrossCheck.jpg
Scientific Editor Work List 12776-Scientific editor work list.pdf