Publication Name	World Journal of Gastroenterology
Manuscript ID	12778
Country	China

Received	2014-07-25 17:56
Peer-Review Started	2014-07-26 13:54
To Make the First Decision	2014-08-27 19:17
Return for Revision	2014-09-03 18:21
Revised	2014-09-16 10:07
Second Decision	2014-10-21 17:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-10-21 17:49
Articles in Press	2014-10-21 18:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-10-28 16:29
Typeset the Manuscript	2015-01-29 19:34
Publish the Manuscript Online	2015-02-11 17:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Autobiography
Article Title	Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Zhang, Bo Jiang, Shi-Tao Zou, Fen Liu and Dong Hua
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Jiangsu Province BK2012542 Hospital Management Center of Wuxi City YGZ1108
Corresponding Author	Dong Hua, MD, PhD, Department of Oncology, Affiliated hospital of Jiangnan University, No. 200 Huihe Road, Binhu District, Wuxi 214062, Jiangsu Province, China. wx89211@163.com
Key Words	B7-H3; Overexpression; Colorectal cancer; B-cell CLL/lymphoma 2; Apoptosis; Signaling pathway; Jak2-STAT3
Core Tip	The expression of B7-H3 has been positively correlated with poor prognosis in colorectal cancer. Previous studies revealed the relationship between B7-H3 and tumor invasion and metastasis. In the present study, the role of B7-H3 in apoptosis in colo?rectal cancer was investigated. Our results showed that overexpression of B7-H3 induced resistance to apoptosis in colorectal cancer cell lines by upregulating the Jak2-STAT3 signaling pathway. These results provide a new vision for designing therapeutics targeting B7-H3 and its associated signaling pathways in the treatment of colorectal cancer.
Publish Date	2015-02-11 17:56
Citation	Zhang T, Jiang B, Zou ST, Liu F, Hua D. Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. World J Gastroenterol 2015; 21(6): 1804-1813
URL	http://www.wjgnet.com/1007-9327/full/v21/i6/1804.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i6.1804

Full Article (PDF)	WJG-21-1804.pdf
Full Article (Word)	WJG-21-1804.doc
Manuscript File	12778-Review.docx
Answering Reviewers	12778-Answering reviewers.pdf
Copyright License Agreement	12778-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12778-Language certificate.pdf
Peer-review Report	12778-Peer review(s).pdf
Scientific Misconduct Check	12778-CrossCheck.jpg
Scientific Editor Work List	12778-Scientific editor work list.pdf