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Articles Published Processes
2/11/2015 5:56:00 PM | Browse: 1254 | Download: 1749
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Received |
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2014-07-25 17:56 |
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Peer-Review Started |
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2014-07-26 13:54 |
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To Make the First Decision |
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2014-08-27 19:17 |
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Return for Revision |
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2014-09-03 18:21 |
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Revised |
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2014-09-16 10:07 |
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Second Decision |
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2014-10-21 17:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-21 17:49 |
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Articles in Press |
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2014-10-21 18:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-28 16:29 |
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Typeset the Manuscript |
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2015-01-29 19:34 |
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Publish the Manuscript Online |
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2015-02-11 17:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Autobiography |
| Article Title |
Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Zhang, Bo Jiang, Shi-Tao Zou, Fen Liu and Dong Hua |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Jiangsu Province |
BK2012542 |
| Hospital Management Center of Wuxi City |
YGZ1108 |
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| Corresponding Author |
Dong Hua, MD, PhD, Department of Oncology, Affiliated hospital of Jiangnan University, No. 200 Huihe Road, Binhu District, Wuxi 214062, Jiangsu Province, China. wx89211@163.com |
| Key Words |
B7-H3; Overexpression; Colorectal cancer; B-cell CLL/lymphoma 2; Apoptosis; Signaling pathway; Jak2-STAT3 |
| Core Tip |
The expression of B7-H3 has been positively correlated with poor prognosis in colorectal cancer. Previous studies revealed the relationship between B7-H3 and tumor invasion and metastasis. In the present study, the role of B7-H3 in apoptosis in colo?rectal cancer was investigated. Our results showed that overexpression of B7-H3 induced resistance to apoptosis in colorectal cancer cell lines by upregulating the Jak2-STAT3 signaling pathway. These results provide a new vision for designing therapeutics targeting B7-H3 and its associated signaling pathways in the treatment of colorectal cancer. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Zhang T, Jiang B, Zou ST, Liu F, Hua D. Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. World J Gastroenterol 2015; 21(6): 1804-1813 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1804.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1804 |
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