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Articles Published Processes
4/14/2015 5:36:00 PM | Browse: 1114 | Download: 1703
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Received |
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2014-07-26 08:01 |
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Peer-Review Started |
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2014-07-27 22:35 |
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To Make the First Decision |
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2014-08-28 15:09 |
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Return for Revision |
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2014-09-01 17:49 |
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Revised |
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2014-09-14 13:52 |
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Second Decision |
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2014-11-21 08:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-12-01 14:04 |
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Articles in Press |
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2014-12-01 14:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-03-24 10:15 |
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Publish the Manuscript Online |
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2015-04-14 17:36 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Therapeutic targets in gastrointestinal stromal tumors
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Qing Zhu and Wen-Bin Ou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Project of Zhejiang Province |
2012C03007-4 |
| Zhejiang Public Technology Research Program |
2014C33234 |
| Zhejiang Provincial Top Key Discipline of Biology, and Science Foundation of Zhejiang Sci-Tech University |
14042107-Y |
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| Corresponding Author |
Dr. Wen-Bin Ou, College of Life Sciences, Zhejiang Sci-Tech University, 866 Yuhangtang Road, Hangzhou 310018, Zhejiang Province, China. ouwenbin@tsinghua.org.cn
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| Key Words |
Gastrointestinal stromal tumors; Tyrosine kinase inhibitors; KIT; Platelet-derived growth factor receptor α; Targets |
| Core Tip |
Oncogenic KIT and platelet-derived growth factor receptor α (PDGFRA) mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GISTs), and the KIT/PDGFRA kinase inhibitors imatinib, sunitinib, and regorafenib are the standards of care for patients with unresectable or metastatic GIST. However, most patients eventually develop resistance to these kinase inhibitors, resulting in an urgent need to identify biologically rational targets for novel therapies. Herein, we review advances in the research on GIST and the therapies that are used to treat it. Additionally, we discuss novel agents, targets, and strategies for the future treatment of GIST.
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| Publish Date |
2015-04-14 17:36 |
| Citation |
Zhu JQ, Ou WB. Therapeutic targets in gastrointestinal stromal tumors. World J Transl Med 2015; 4(1): 25-37 |
| URL |
http://www.wjgnet.com/2220-6132/full/v4/i1/25.htm |
| DOI |
http://dx.doi.org/10.5528/wjtm.v4.i1.25 |
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