Publication Name	World Journal of Hepatology
Manuscript ID	12800
Country	Japan

Received	2014-07-26 13:43
Peer-Review Started	2014-07-27 22:15
To Make the First Decision	2014-08-14 14:49
Return for Revision	2014-08-18 09:20
Revised	2014-08-31 20:00
Second Decision	2014-10-16 15:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-10-16 15:43
Articles in Press	2014-10-16 15:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-03 16:59
Publish the Manuscript Online	2014-12-13 17:50

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Palliative external-beam radiotherapy for bone metastases from hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Shinya Hayashi, Hidekazu Tanaka and Hiroaki Hoshi
Funding Agency and Grant Number
Corresponding Author	Shinya Hayashi, MD, Assistant Professor, Department of Radiology, Gifu University Hospital, Yanagido 1-1, Gifu 501-1194, Japan. shayashi@gifu-u.ac.jp
Key Words	Hepatocellular carcinoma; Metastasis; Radiotherapy; Palliative therapy; Spinal cord compression; Skull base metastasis
Core Tip	Due to a lack of clinical data, external-beam radiotherapy (EBRT) for bone metastases (BMs) from hepatocellular carcinoma (HCC) is still not widely used as a palliative therapy component, and the optimal dosing schedule remains unclear. BMs from HCC typically occur as expansive, bulky soft-tissue masses; they exhibit expansive growth that compresses the peripheral nerves, spinal cord, or cranial nerves, causing both bone and neuropathic pain, and neurological symptoms. In this review, we outline the data describing palliative EBRT for BMs from HCC to treat bone pain, spinal compression, and skull base metastases.
Publish Date	2014-12-13 17:50
Citation	Hayashi S, Tanaka H, Hoshi H. Palliative external-beam radiotherapy for bone metastases from hepatocellular carcinoma. World J Hepatol 2014; 6(12): 923-929
URL	http://www.wjgnet.com/1948-5182/full/v6/i12/923.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i12.923

Full Article (PDF)	WJH-6-923.pdf
Full Article (Word)	WJH-6-923.doc
Manuscript File	12800-Review.doc
Answering Reviewers	12800-Answering reviewers.pdf
Copyright License Agreement	12800-Copyright assignment.pdf
Peer-review Report	12800-Peer review(s).pdf
Scientific Misconduct Check	12800-CrossCheck.jpg
Scientific Editor Work List	12800-Scientific editor work list.pdf