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Articles Published Processes
10/13/2026 9:29:21 AM | Browse: 1 | Download: 0
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Received |
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2026-09-17 03:39 |
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Peer-Review Started |
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2026-09-17 03:40 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-29 06:32 |
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Revised |
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2026-09-30 00:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-10 08:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-10 09:01 |
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Articles in Press |
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2026-10-10 09:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-12 05:40 |
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Publish the Manuscript Online |
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2026-10-13 09:29 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Case Report |
| Article Title |
Suspected donepezil withdrawal syndrome in an older woman with Alzheimer disease of abrupt cessation: A case report
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Takahiko Nagamine |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Takahiko Nagamine, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp |
| Key Words |
Donepezil; Withdrawal syndrome; Delirium; Behavioral and psychological symptoms of dementia; Nursing-home admission; Older adults; Case report |
| Core Tip |
Abrupt discontinuation of long-term donepezil was followed 48 hours later by agitation, insomnia and gait instability in an 89-year-old woman who had taken 10 mg/day for more than five years. Symptoms improved after rechallenge with 5 mg/day, but interpretation is limited by pre-existing cognitive decline, nursing-home relocation, concomitant quetiapine and other unmeasured factors. The case illustrates why suspected withdrawal may be considered in the differential diagnosis without assuming that all post-discontinuation deterioration is drug-related. |
| Publish Date |
2026-10-13 09:29 |
| Citation |
Nagamine T. Suspected donepezil withdrawal syndrome in an older woman with Alzheimer disease of abrupt cessation: A case report. World J Clin Cases 2026; 14(27): 128223
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| URL |
https://www.wjgnet.com/2307-8960/full/v14/i27/128223.htm |
| DOI |
https://doi.org/10.12998/wjcc.128223 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
