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Articles Published Processes
3/20/2015 10:48:00 AM | Browse: 1197 | Download: 1390
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Received |
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2014-07-27 15:06 |
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Peer-Review Started |
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2014-07-27 23:15 |
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To Make the First Decision |
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2014-08-28 15:08 |
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Return for Revision |
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2014-09-01 17:25 |
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Revised |
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2014-09-25 10:06 |
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Second Decision |
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2014-11-03 16:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-03 17:11 |
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Articles in Press |
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2014-11-03 17:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-02-12 12:06 |
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Publish the Manuscript Online |
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2015-03-20 10:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Mitochondria as therapeutic targets for cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
In Sung Song, Jeong Yu Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim and Jin Han |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology |
2010-0020224 |
| Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology |
2012R1A1A2041700 |
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| Corresponding Author |
Jin Han, MD, PhD, National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633-165 Gaegeum-dong, Busanjin-gu, Busan 614-735, South Korea. phyhanj@inje.ac.kr |
| Key Words |
Cancer stem cells; Mitochondria; Relapsed and refractory cancer; Therapeutic target; Mitochondrial energy metabolism |
| Core Tip |
This review is devoted to the analysis of mitochondrial function as a therapeutic target to induce cell death in cancer stem cells (CSCs). In particular, we focused on the differences in energy metabolism and features between CSC and non-CSC mitochondria, and between CSCs and normal stem cells. We described the roles of mitochondria that may make CSCs more susceptible to anti-cancer treatment and apoptosis, and how these may be useful to develop novel strategies for cancer treatment, such as through combined therapy with specific mitochondrial-targeting drugs. |
| Publish Date |
2015-03-20 10:47 |
| Citation |
Song IS, Jeong JY, Jeong SH, Kim HK, Ko KS, Rhee BD, Kim N, Han J. Mitochondria as therapeutic targets for cancer stem cells. World J Stem Cells 2015; 7(2): 418-427 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i2/418.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i2.418 |
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