Publication Name	World Journal of Stem Cells
Manuscript ID	12825
Country	South Korea

Received	2014-07-27 15:06
Peer-Review Started	2014-07-27 23:15
First Decision by Editorial Office Director
Return for Revision	2014-09-01 17:25
Revised	2014-09-25 10:06
Publication Fee Transferred
Second Decision by Editor	2014-11-03 16:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-11-03 17:11
Articles in Press	2014-11-03 17:12
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-12 12:06
Publish the Manuscript Online	2015-03-20 10:47

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Mitochondria as therapeutic targets for cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	In Sung Song, Jeong Yu Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim and Jin Han
Funding Agency and Grant Number	Funding Agency Grant Number Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology 2010-0020224 Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology 2012R1A1A2041700
Corresponding Author	Jin Han, MD, PhD, National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633-165 Gaegeum-dong, Busanjin-gu, Busan 614-735, South Korea. phyhanj@inje.ac.kr
Key Words	Cancer stem cells; Mitochondria; Relapsed and refractory cancer; Therapeutic target; Mitochondrial energy metabolism
Core Tip	This review is devoted to the analysis of mitochondrial function as a therapeutic target to induce cell death in cancer stem cells (CSCs). In particular, we focused on the differences in energy metabolism and features between CSC and non-CSC mitochondria, and between CSCs and normal stem cells. We described the roles of mitochondria that may make CSCs more susceptible to anti-cancer treatment and apoptosis, and how these may be useful to develop novel strategies for cancer treatment, such as through combined therapy with specific mitochondrial-targeting drugs.
Publish Date	2015-03-20 10:47
Citation	Song IS, Jeong JY, Jeong SH, Kim HK, Ko KS, Rhee BD, Kim N, Han J. Mitochondria as therapeutic targets for cancer stem cells. World J Stem Cells 2015; 7(2): 418-427
URL	http://www.wjgnet.com/1948-0210/full/v7/i2/418.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i2.418

Full Article (PDF)	WJSC-7-418.pdf
Full Article (Word)	WJSC-7-418.doc
Manuscript File	12825-Review.docx
Answering Reviewers	12825-Answering reviewers.pdf
Copyright License Agreement	12825-Copyright assignment.pdf
Peer-review Report	12825-Peer review(s).pdf
Scientific Misconduct Check	12825-CrossCheck.jpg
Scientific Editor Work List	12825-Scientific editor work list.pdf