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Articles Published Processes
2/9/2015 5:58:00 PM | Browse: 1124 | Download: 1317
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Received |
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2014-07-27 16:35 |
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Peer-Review Started |
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2014-07-28 08:32 |
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To Make the First Decision |
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2014-08-06 17:25 |
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Return for Revision |
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2014-08-15 18:31 |
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Revised |
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2014-08-28 16:54 |
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Second Decision |
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2014-10-21 17:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-21 17:47 |
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Articles in Press |
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2014-10-21 18:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-11-17 07:48 |
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Typeset the Manuscript |
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2015-01-25 14:38 |
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Publish the Manuscript Online |
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2015-02-09 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ping Li, Xu-Dong Tang, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu and Hui-Shu Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81273919 |
| Natural Science Foundation of Liaoning Province |
2012225020 |
| Natural Science Foundation of Liaoning Province |
2013023002 |
| National Basic Research Program of China（973 Program） |
2013CB531703 |
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| Corresponding Author |
Hui-Shu Guo, Professor, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. guohuishu1@126.com |
| Key Words |
C-Type natriuretic peptide; Natriuretic peptide receptor type B; Rectum; Depression; Gastrointestinal motility |
| Core Tip |
C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) were expressed in the mucosa, muscle, and serosa of rat rectum. Expression of CNP and NPR-B are upregulated in the rectum of depressive digestive disorder rats, with the CNP/NPR-B signal pathway possibly being involved in depressive digestive disorders. Our study shows that Xiaoyaosan inhibits the expression of CNP and NPR-B in a dose-dependent manner. |
| Publish Date |
2015-02-09 17:58 |
| Citation |
Li P, Tang XD, Cai ZX, Qiu JJ, Lin XL, Zhu T, Owusu L, Guo HS. CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan. World J Gastroenterol 2015; 21(5): 1518-1530 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i5/1518.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i5.1518 |
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