Publication Name	World Journal of Gastroenterology
Manuscript ID	12849
Country	China

Received	2014-07-28 09:07
Peer-Review Started	2014-07-30 08:11
First Decision by Editorial Office Director
Return for Revision	2014-08-18 15:10
Revised	2014-09-02 10:34
Publication Fee Transferred
Second Decision by Editor	2014-10-15 12:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-10-15 17:49
Articles in Press	2014-10-15 18:01
Edit the Manuscript by Language Editor	2014-10-28 11:58
Typeset the Manuscript	2015-04-28 14:10
Publish the Manuscript Online	2015-05-18 17:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence
Manuscript Source	Unsolicited Manuscript
All Author List	Qing Pang, Jing-Yao Zhang, Xin-Sen Xu, Si-Dong Song, Kai Qu, Wei Chen, Yan-Yan Zhou, Run-Chen Miao, Su-Shun Liu, Ya-Feng Dong and Chang Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30872482 National Natural Science Foundation of China 81072051
Corresponding Author	Chang Liu, MD, PhD, Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, No. 277 West Yan-ta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Key Words	Alkaline phosphatase; Alpha-fetoprotein; Aspartate aminotransferase; Blood platelets; Hepatocellular carcinoma; Recurrence
Core Tip	The high risk of postoperative recurrence is one of the greatest problems plaguing potential curative treatment for hepatocellular carcinoma (HCC). Although several prognostic models have been proposed for HCC, these indices mainly focus on non-modifiable tumor characteristics. In contrast, platelet count is an improvable variable, and there are numerous platelet-based models associated with cirrhosis and HCC formation. We found that platelet count and nearly half of the established platelet-related models were independently associated with postoperative recurrence. We also demonstrated different risk factors between early and late recurrences, with platelets more likely to influence late recurrence.
Publish Date	2015-05-18 17:02
Citation	Pang Q, Zhang JY, Xu XS, Song SD, Qu K, Chen W, Zhou YY, Miao RC, Liu SS, Dong YF, Liu C. Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence. World J Gastroenterol 2015; 21(18): 5607-5621
URL	http://www.wjgnet.com/1007-9327/full/v21/i18/5607.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i18.5607

Full Article (PDF)	WJG-21-5607.pdf
Full Article (Word)	WJG-21-5607.doc
Manuscript File	12849-Review.docx
Answering Reviewers	12849-Answering reviewers.pdf
Copyright License Agreement	12849-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12849-Language certificate.pdf
Peer-review Report	12849-Peer reviews.pdf
Scientific Misconduct Check	12849-CrossCheck.jpg
Scientific Editor Work List	12849-Scientific editor work list.pdf