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Articles Published Processes
1/14/2015 11:53:00 AM | Browse: 1300 | Download: 1315
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Received |
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2014-07-28 08:22 |
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Peer-Review Started |
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2014-07-28 19:12 |
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To Make the First Decision |
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2014-09-04 09:28 |
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Return for Revision |
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2014-09-04 16:47 |
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Revised |
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2014-09-16 03:56 |
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Second Decision |
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2014-09-19 11:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-19 11:08 |
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Articles in Press |
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2014-09-19 11:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-12-18 10:59 |
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Publish the Manuscript Online |
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2015-01-14 11:53 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β Cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Essam M Abdelalim and Mohamed M Emara |
| Funding Agency and Grant Number |
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| Corresponding Author |
Essam M Abdelalim, PhD, Qatar Biomedical Research Institute, Qatar Foundation, Education City, PO Box 5825, Doha, Qatar. emohamed@qf.org.qa |
| Key Words |
Embryonic stem cells; Induced pluripotent stem cells; Insulin-secreting cells; In vitro; In vivo; Differentiation; Maturation |
| Core Tip |
Pluripotent stem cells (PSCs) including induced PSCs and embryonic stem cells are valuable sources for cell replacement therapies and disease modeling of diabetes. Although several studies reported the differentiation of PSCs into pancreatic β cells in vivo, still their response to glucose is very limited in vitro due to their immature nature. In this review, we summarize the current knowledge about the differentiation of PSCs into pancreatic β cells and discuss the challenges facing the differentiation and application of PSC-derived β cells. |
| Publish Date |
2015-01-14 11:53 |
| Citation |
Abdelalim EM, Emara MM. Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells. World J Stem Cells 2015; 7(1): 174-181 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i1/174.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i1.174 |
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