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Articles Published Processes
12/12/2014 11:15:00 AM | Browse: 1069 | Download: 1502
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Received |
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2014-07-29 10:07 |
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Peer-Review Started |
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2014-07-30 12:04 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-09-18 11:52 |
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Revised |
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2014-10-01 20:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-10-29 18:02 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-10-29 18:57 |
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Articles in Press |
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2014-10-29 18:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-28 17:54 |
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Publish the Manuscript Online |
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2014-12-12 11:14 |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Telomerase activity: An attractive target for cancer therapeutics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lucia Picariello, Cecilia Grappone, Simone Polvani and Andrea Galli |
| Funding Agency and Grant Number |
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| Corresponding Author |
Andrea Galli, MD, PhD, Professor, Gastroenterology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini n°6, 50139 Florence, Italy. andrea.galli@unifi.it |
| Key Words |
Human telomerase reverse transcriptase; Immunotherapy; Suicide gene therapy; Acycloguanosyl 5’-thymidyltriphosphate; Telomerase inhibition |
| Core Tip |
One of the hallmark of cancer is the replicative immortality of tumor cells guaranteed by telomerase activity that counteracts progressive telomere shortening during cellular replication: this makes telomerase a tumor marker and a target for anticancer drugs. In this review we summarize and update the most recent innovative studies and results on the different strategies that consider telomerase as a target for cancer therapy. In particular, we try to point out the advantages and the potentialities of some innovative approaches, compared to other, equally promising, but that need further investigations. |
| Publish Date |
2014-12-12 11:14 |
| Citation |
Picariello L, Grappone C, Polvani S, Galli A. Telomerase activity: An attractive target for cancer therapeutics. World J Pharmacol 2014; 3(4): 86-96 |
| URL |
http://www.wjgnet.com/2220-3192/full/v3/i4/86.htm |
| DOI |
http://dx.doi.org/10.5497/wjp.v3.i4.86 |
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