Publication Name	World Journal of Stem Cells
Manuscript ID	12896
Country	Italy

Received	2014-07-29 10:05
Peer-Review Started	2014-07-30 11:34
To Make the First Decision	2014-08-14 14:33
Return for Revision	2014-08-18 12:03
Revised	2014-09-08 19:58
Second Decision	2014-09-17 14:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-17 14:29
Articles in Press	2014-09-17 14:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-22 17:36
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Research & Experimental Medicine
Manuscript Type	Minireviews
Article Title	Potential advantages of acute kidney injury management by mesenchymal stem cells
Manuscript Source	Invited Manuscript
All Author List	Bianchi Francesca, Sala Elisa, Donadei Chiara, Capelli Irene and La Manna Gaetano
Funding Agency and Grant Number
Corresponding Author	Gaetano La Manna, MD, PhD, Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, St Orsola Hospital, University of Bologna, Via Zamboni, 33, 40128 Bologna, Italy. gaetano.lamanna@unibo.it
Key Words	Mesenchymal stem cells; Paracrine; Soluble factors; Microvesicle; Acute kidney injury; Regenerative medicine; Preclinical; Clinical trial
Core Tip	Mesenchymal stem cells (MSCs) may have an important therapeutic potential in acute kidney injury management. A body of evidence has demonstrated that MSCs act through a paracrine/endocrine secretion of soluble factors and microvesicles. We summarize preclinical studies and ongoing clinical trials that evaluate the role of MSCs in restoring kidney function. We critically explain the current concerns about the use of MSCs and microvesicles that limit their applications in clinical trials. Then, we propose the future directions that could lead to extend MSCs use in humans.
Publish Date	2014-09-28 14:56
Citation	Bianchi F, Sala E, Donadei C, Capelli I, La Manna G. Potential advantages of acute kidney injury management by mesenchymal stem cells. World J Stem Cells 2014; 6(5): 644-650
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/644.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.644

Full Article (PDF)	WJSC-6-644.pdf
Full Article (Word)	WJSC-6-644.doc
Manuscript File	12896-Review.doc
Answering Reviewers	12896-Answering reviewers.pdf
Copyright License Agreement	12896-Copyright assignment.pdf
Peer-review Report	12896-Peer review(s).pdf
Scientific Misconduct Check	12896-CrossCheck.jpg
Scientific Editor Work List	12896-Scientific editor work list.pdf