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9/28/2014 2:57:00 PM | Browse: 580 | Download: 698
Publication Name World Journal of Stem Cells
Manuscript ID 12896
Country/Territory Italy
Received
2014-07-29 10:05
Peer-Review Started
2014-07-30 11:34
To Make the First Decision
2014-08-14 14:33
Return for Revision
2014-08-18 12:03
Revised
2014-09-08 19:58
Second Decision
2014-09-17 14:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-17 14:29
Articles in Press
2014-09-17 14:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-22 17:36
Publish the Manuscript Online
2014-09-28 14:56
ISSN 1948-0210 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research and Experimental Medicine
Manuscript Type Minireviews
Article Title Potential advantages of acute kidney injury management by mesenchymal stem cells
Manuscript Source Invited Manuscript
All Author List Bianchi Francesca, Sala Elisa, Donadei Chiara, Capelli Irene and La Manna Gaetano
Funding Agency and Grant Number
Corresponding author Gaetano La Manna, MD, PhD, Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, St Orsola Hospital, University of Bologna, Via Zamboni, 33, 40128 Bologna, Italy. gaetano.lamanna@unibo.it
Keywords Mesenchymal stem cells; Paracrine; Soluble factors; Microvesicle; Acute kidney injury; Regenerative medicine; Preclinical; Clinical trial
Core Tip Mesenchymal stem cells (MSCs) may have an important therapeutic potential in acute kidney injury management. A body of evidence has demonstrated that MSCs act through a paracrine/endocrine secretion of soluble factors and microvesicles. We summarize preclinical studies and ongoing clinical trials that evaluate the role of MSCs in restoring kidney function. We critically explain the current concerns about the use of MSCs and microvesicles that limit their applications in clinical trials. Then, we propose the future directions that could lead to extend MSCs use in humans.
Publish Date 2014-09-28 14:56
Citation Bianchi F, Sala E, Donadei C, Capelli I, La Manna G. Potential advantages of acute kidney injury management by mesenchymal stem cells. World J Stem Cells 2014; 6(5): 644-650
Url http://www.wjgnet.com/1948-0210/full/v6/i5/644.htm
DOI http://dx.doi.org/10.4252/wjsc.v6.i5.644
Full Article (PDF) WJSC-6-644.pdf
Full Article (Word) WJSC-6-644.doc
Manuscript File 12896-Review.doc
Answering Reviewers 12896-Answering reviewers.pdf
Copyright License Agreement 12896-Copyright assignment.pdf
Peer-review Report 12896-Peer review(s).pdf
Scientific Misconduct Check 12896-CrossCheck.jpg
Scientific Editor Work List 12896-Scientific editor work list.pdf