Publication Name	World Journal of Stem Cells
Manuscript ID	12911
Country	Belgium

Received	2014-07-29 09:31
Peer-Review Started	2014-07-29 23:23
To Make the First Decision	2014-09-04 09:28
Return for Revision	2014-09-04 17:04
Revised	2014-10-07 19:31
Second Decision	2014-11-12 13:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-11-19 11:14
Articles in Press	2014-11-19 11:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-07 12:01
Publish the Manuscript Online	2015-03-20 10:47

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury
Manuscript Source	Invited Manuscript
All Author List	Charles Nicaise, Dinko Mitrecic, Aditi Falnikar and Angelo C Lepore
Funding Agency and Grant Number	Funding Agency Grant Number NINDS #1R01NS079702(to Angelo C Lepore)
Corresponding Author	Charles Nicaise, PhD, Assistant Professor, Laboratory Neurodegeneration and Regeneration, URPhyM-NARILIS, Faculty of Medicine, University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium. charles.nicaise@unamur.be
Key Words	Neuroprotection; Stem cell; Cell therapy; Astrocyte; Transplantation; Amyotrophic lateral sclerosis; Spinal cord injury
Core Tip	Amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI) result in incurable neurological dysfunction due to loss of spinal motor neurons and axonal degeneration, amongst other mechanisms. Astrocytes are increasingly recognized as being necessary for neuroprotection and regeneration in the central nervous system as they promote axonal growth and deliver essential neurotrophic factors under both physiological and pathophysiological conditions. Given the central role played by astrocytes, we gathered convincing results from ALS and SCI literature that argue in favor of stem cell-based astrocyte replacement therapies and stress the scientific community to investigate more deeply the molecular understanding of astrocyte biology.
Publish Date	2015-03-20 10:47
Citation	Nicaise C, Mitrecic D, Falnikar A, Lepore AC. Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury. World J Stem Cells 2015; 7(2): 380-398
URL	http://www.wjgnet.com/1948-0210/full/v7/i2/380.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i2.380

Full Article (PDF)	WJSC-7-380.pdf
Full Article (Word)	WJSC-7-380.doc
Manuscript File	12911-Review.docx
Answering Reviewers	12911-Answering reviewers.pdf
Copyright License Agreement	12911-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12911-Scientific editor work list.pdf
Peer-review Report	12911-Peer review(s).pdf
Scientific Misconduct Check	12911-CrossCheck.jpg
Scientific Editor Work List	12911-Scientific editor work list.pdf