Publication Name	World Journal of Clinical Cases
Manuscript ID	12941
Country

Received	2014-07-29 10:01
Peer-Review Started	2014-07-29 17:40
To Make the First Decision	2014-09-16 10:48
Return for Revision	2014-09-18 13:44
Revised	2014-10-03 00:45
Second Decision	2014-11-12 13:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-19 11:16
Articles in Press	2014-11-19 11:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-22 10:23
Publish the Manuscript Online	2015-02-05 16:28

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Genetics & Heredity
Manuscript Type	Review
Article Title	Review and update on the molecular basis of Leber congenital amaurosis
Manuscript Source	Invited Manuscript
All Author List	Oscar Francisco Chacon-Camacho and Juan Carlos Zenteno
Funding Agency and Grant Number
Corresponding Author	Dr. Juan Carlos Zenteno, Genetics Department-Research Unit, Institute of Ophthalmology, "Conde de Valenciana", Chimalpopoca #14, Col. Obrera, Cuauhtemoc, Mexico City 06800, Mexico. jczenteno@institutodeoftalmologia.org
Key Words	Gene therapy; Leber congenital amaurosis; Retinal dystrophies; Childhood blindness
Core Tip	Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness before the age of 1 year. Clinical ophthalmological findings together with electroretinogram study, OCT imaging and retinal molecular-genetic technologies provide a precise diagnosis in these individuals. Gene-specific phenotypic features exist in LCA, and in this way is possible to predict the underlying genetic defect in some patients on the basis of ophthalmological clues. Clinical, molecular-genetics, phenotype-genotype and gene therapy aspects of LCA are described.
Publish Date	2015-02-05 16:28
Citation	Chacon-Camacho OF, Zenteno JC. Review and update on the molecular basis of Leber congenital amaurosis. World J Clin Cases 2015; 3(2): 112-124
URL	http://www.wjgnet.com/2307-8960/full/v3/i2/112.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i2.112

Full Article (PDF)	WJCC-3-112.pdf
Full Article (Word)	WJCC-3-112.doc
Manuscript File	12941-Review.doc
Answering Reviewers	12941-Answering reviewers.pdf
Copyright License Agreement	12941-Copyright assignment.pdf
Peer-review Report	12941-Peer review(s).pdf
Scientific Misconduct Check	12941-CrossCheck.jpg
Scientific Editor Work List	12941-Scientific editor work list.pdf