Publication Name	World Journal of Gastroenterology
Manuscript ID	12956
Country	China

Received	2014-07-30 09:45
Peer-Review Started	2014-07-31 13:14
To Make the First Decision	2014-08-27 19:07
Return for Revision	2014-09-09 11:16
Revised	2014-09-20 22:13
Second Decision	2014-11-27 11:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-08 16:19
Articles in Press	2014-12-08 17:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-01-07 07:55
Typeset the Manuscript	2015-04-03 09:07
Publish the Manuscript Online	2015-04-20 15:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	H2S down-regulates severe acute pancreatitis through the PI3K/AKT-NF-κB pathway in vivo
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Yan Rao, Lan-Ying Fu, Chang-Lun Hu, Dai-Xing Chen, Tian Gan, Yi-Cheng Wang and Xiao-Yan Zhao
Funding Agency and Grant Number
Corresponding Author	Xiao-Yan Zhao, Professor, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing 400037, China. zhaoxx@medmail.com.cn
Key Words	Severe acute pancreatitis; H2S; Cystathionine-γ-lyase; Cytokine; Signaling pathway
Core Tip	In this research, we provide a wild-ranging different dosages of exogenous H2S (NaHS), from 5 mg/kg to 100 mg/kg to study the role of H2S in severe acute pancreatitis (SAP) in vivo, and finally find that the level of H2S was reduced in rat SAP models, suggesting that H2S donor NaHS reduced the inflammatory indices of SAP, by inhibiting PI3K/AKT phosphorylation, the down-regulation of IκBα degration, and NF-κB activity.
Publish Date	2015-04-20 15:10
Citation	Rao CY, Fu LY, Hu CL, Chen DX, Gan T, Wang YC, Zhao XY. H2S mitigates severe acute pancreatitis through the PI3K/AKT-NF-κB pathway in vivo. World J Gastroenterol 2015; 21(15): 4555-4563
URL	http://www.wjgnet.com/1007-9327/full/v21/i15/4555.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i15.4555

Full Article (PDF)	WJG-21-4555.pdf
Full Article (Word)	WJG-21-4555.doc
Manuscript File	12956-Review.docx
Answering Reviewers	12956-Answering reviewers.pdf
Copyright License Agreement	12956-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12956-Language certificate.pdf
Peer-review Report	12956-Peer review(s).pdf
Scientific Misconduct Check	12956-CrossCheck.jpg
Scientific Editor Work List	12956-Scientific editor work list.pdf