Publication Name	World Journal of Hepatology
Manuscript ID	12985
Country	Spain

Received	2014-07-31 20:02
Peer-Review Started	2014-08-01 17:29
To Make the First Decision	2014-09-16 11:08
Return for Revision	2014-09-27 10:51
Revised	2015-01-31 23:27
Second Decision	2015-02-27 09:25
Accepted by Journal Editor-in-Chief	2015-02-27 21:23
Accepted by Executive Editor-in-Chief	2015-03-09 16:48
Articles in Press	2015-03-09 16:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-15 16:31
Publish the Manuscript Online	2015-06-03 12:00

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	Liver steatosis in hepatitis C patients
Manuscript Source	Invited Manuscript
All Author List	Emilio González-Reimers, Geraldine Quintero-Platt, Melchor Rodríguez-Gaspar, Remedios Alemán-Valls, Onán Pérez-Hernández and Francisco Santolaria-Fernández
Funding Agency and Grant Number
Corresponding Author	Dr. Emilio González-Reimers, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Ofra s/n, Tenerife, 38320 Canary Islands, Spain. egonrey@ull.es
Key Words	Hepatitis C virus steatosis adiponectin; Leptin; Insulin resistance; Proinflammatory cytokines; Triglyceride synthesis; Fatty acid oxidation
Core Tip	Chronic hepatitis C virus (HCV) infection can lead to steatosis and steatohepatitis. Increased liver triglyceride synthesis is mediated by several transcription factors such as sterol regulatory element-binding protein (SREBP) whose expression is enhanced, in turn, by HCV core protein. Chronic HCV infection is also associated with insulin resistance that seems to be selective because although it activates systemic lipolysis, it increases triglyceride synthesis within the liver. This is due to the stimulatory effect of insulin on SREBP. It remains to be answered why not all patients with HCV infection and steatosis develop steatohepatitis despite early cytokine activation and metabolic derangements.
Publish Date	2015-06-03 12:00
Citation	González-Reimers E, Quintero-Platt G, Rodríguez-Gaspar M, Alemán-Valls R, Pérez-Hernández O, Santolaria-Fernández F. Liver steatosis in hepatitis C patients. World J Hepatol 2015; 7(10): 1337-1346
URL	http://www.wjgnet.com/1948-5182/full/v7/i10/1337.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i10.1337

Full Article (PDF)	WJH-7-1337.pdf
Full Article (Word)	WJH-7-1337.doc
Manuscript File	12985-Review.doc
Answering Reviewers	12985-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12985-Conflict-of-interest statement.pdf
Copyright License Agreement	12985-Copyright assignment.pdf
Peer-review Report	12985-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	12985-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	12985-Scientific misconduct check.pdf
Scientific Editor Work List	12985-Scientific editor work list.pdf