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Articles Published Processes
3/16/2015 6:04:00 PM | Browse: 1049 | Download: 1216
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Received |
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2014-08-01 09:17 |
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Peer-Review Started |
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2014-08-02 22:53 |
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To Make the First Decision |
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2014-08-27 19:08 |
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Return for Revision |
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2014-09-09 10:44 |
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Revised |
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2014-09-20 13:27 |
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Second Decision |
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2014-11-19 08:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-12-01 13:35 |
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Articles in Press |
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2014-12-01 13:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-13 07:38 |
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Typeset the Manuscript |
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2015-03-03 10:52 |
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Publish the Manuscript Online |
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2015-03-16 18:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibitory effect of TongXie-YaoFang formula on colonic contraction in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng Yang, Sheng-Sheng Zhang, Xiao-Ling Li, Zheng-Fang Wang and Lu-Qing Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81473644 |
| Clinical Medicine Development Project of Beijing Municipal Administration of Hospitals |
ZY201411 |
| Health Technical Personnel of the Beijing Health System |
2011-2-13 |
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| Corresponding Author |
Sheng-Sheng Zhang, PhD, Professor, Digestive Disease Diagnosis and Treatment Center, Beijing Chinese Medicine Hospital, Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China. zhss2000@163.com |
| Key Words |
Irritable bowel syndrome; Neonatal maternal separation; Herbal medicine; Colonic longitudinal smooth muscle; Potassium channel |
| Core Tip |
Diarrhea-predominant irritable bowel syndrome (D-IBS) is a chronic gastrointestinal disease that seriously affects quality of life. Colon dysmotility is recognized as one of the pathophysiological factors. TongXie-YaoFang formula can effectively relieve diarrhea and lower visceral hypersensitivity in D-IBS rats, mainly via inhibiting the amplitude and frequency of colonic longitudinal smooth muscle contraction. Its action of mechanism may be related to the activation of specific potassium channels, inhibition of extracellular calcium internal flow, and reduction of intracellular free Ca2+ concentration. |
| Publish Date |
2015-03-16 18:04 |
| Citation |
Yang C, Zhang SS, Li XL, Wang ZF, Zhao LQ. Inhibitory effect of TongXie-YaoFang formula on colonic contraction in rats. World J Gastroenterol 2015; 21(10): 2912-2917 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i10/2912.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i10.2912 |
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