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Articles Published Processes
1/14/2015 11:53:00 AM | Browse: 1407 | Download: 2603
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Received |
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2014-08-01 09:04 |
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Peer-Review Started |
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2014-08-02 09:58 |
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To Make the First Decision |
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2014-08-28 14:45 |
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Return for Revision |
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2014-09-03 16:03 |
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Revised |
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2014-09-23 04:22 |
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Second Decision |
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2014-10-27 16:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-27 17:11 |
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Articles in Press |
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2014-10-27 17:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-12-22 11:03 |
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Publish the Manuscript Online |
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2015-01-14 11:53 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Cancer stem cell plasticity and tumor hierarchy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marina Carla Cabrera, Robert E Hollingsworth and Elaine M Hurt |
| Funding Agency and Grant Number |
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| Corresponding Author |
Elaine M Hurt, PhD, MedImmune, LLC, Department of Oncology Research, 1 MedImmune Way, Gaithersburg, MD 20878, United States. hurte@medimmune.com |
| Key Words |
Cancer stem cells; Stem cell; Plasticity; Tumor hierarchy; Microenvironment; Immune-mediated therapies; Epithelial-to-mesenchymal transition |
| Core Tip |
The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell (CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer. |
| Publish Date |
2015-01-14 11:53 |
| Citation |
Cabrera MC, Hollingsworth RE, Hurt EM. Cancer stem cell plasticity and tumor hierarchy. World J Stem Cells 2015; 7(1): 27-36 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i1/27.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i1.27 |
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