Publication Name	World Journal of Gastroenterology
Manuscript ID	1313
Country	South Korea

Received	2012-12-01 18:45
Peer-Review Started	2012-12-04 11:20
To Make the First Decision	2013-01-05 12:45
Return for Revision	2013-01-08 12:20
Revised	2013-01-18 10:22
Second Decision	2013-02-06 11:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-02-06 12:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-02 15:15
Publish the Manuscript Online	2013-04-14 19:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Disease progression in chronic hepatitis C patients with normal alanine aminotransferase levels
Manuscript Source	Invited Manuscript
All Author List	Dong Hyun Sinn, Geum-Youn Gwak, Jae-uk Shin, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik and Byung Chul Yoo
Funding Agency and Grant Number
Corresponding Author	Geum-Youn Gwak, MD, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-Gu, Seoul 135-710, South Korea. gy.gwak@samsung.com
Key Words	Alanine aminotransferase; Upper limits of normal; Disease progression; Hepatitis C virus; Hepatocellular carcinoma
Core Tip	Recent studies have indicated that the upper limit of normal for the serum alanine aminotransferase (ALT) level should be lowered. However, outcome studies based on the development of adverse events during long-term follow-up are limited. In this present study, among patients infected with chronic hepatitis C virus who had normal ALT levels, the risk of disease progression differed between patients with "high-normal" and "low-normal" ALT levels, even within the currently accepted normal levels. This finding suggests that lowering the normal threshold of ALT levels may be necessary to better identify patients who are at increased risk for disease progression.
Publish Date	2013-04-14 19:05
Citation	Sinn DH, Gwak GY, Shin J, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC. Disease progression in chronic hepatitis C patients with normal alanine aminotransferase levels. World J Gastroenterol 2013; 19(14): 2256-2261
URL	http://www.wjgnet.com/1007-9327/full/v19/i14/2256.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i14.2256

Full Article (PDF)	WJG-19-2256.pdf
Manuscript File	1313-Review.doc
Answering Reviewers	1313-Answering reviewers.pdf
Copyright License Agreement	1313-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1313-Language certificate.pdf
Peer-review Report	1313-Peer review.docx
Scientific Editor Work List	1313-Scientific editor work list.doc