Publication Name	World Journal of Gastroenterology
Manuscript ID	13130
Country	Italy

Received	2014-08-07 08:37
Peer-Review Started	2014-08-08 09:11
To Make the First Decision	2014-08-27 19:12
Return for Revision	2014-08-28 10:07
Revised	2014-09-30 06:08
Second Decision	2014-11-10 16:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-19 09:26
Articles in Press	2014-11-19 09:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-18 22:56
Typeset the Manuscript	2015-03-30 19:02
Publish the Manuscript Online	2015-04-15 11:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Failure of interferon- pre-treated mesenchymal stem cell treatment in a patient with crohn’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Andrea Taddio, Alberto Tommasini, Erica Valencic, Ettore Biagi, Giuliana Decorti, Sara De Iudicibus, Eva Cuzzoni, Giuseppe Gaipa, Raffaela Badolato, Alberto Prandini, Andrea Biondi and Alessandro Ventura
Funding Agency and Grant Number
Corresponding Author	Andrea Taddio, MD, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo” - Trieste and University of Trieste, via dell’Istria 65/1, 34100 Trieste, Italy. andrea.taddio@burlo.trieste.it
Key Words	Autoimmune disease; Crohn’s disease; Interferon- pretreatment; Mesenchymal stem cells; Immune regulation
Core Tip	This is the first report of a lack of clinical response using interferon-? pre-treated mesenchymal stem cell infusion in a patient with intractable Crohn’s disease. Data on the clinical effects of mesenchymal stem cell treatment in autoimmune disorders are sparse and usually report a good clinical response; however, since very few reports have been published, we think negative results are also worthy of attention. The use of mesenchymal stem cells pre-treated with interferon-? is also of interest, and the lack of clinical benefit of bone marrow-derived interferon-? pre-treated mesenchymal stem cell infusion has also been described, despite the lymphocyte immune regulation effect.
Publish Date	2015-04-15 11:01
Citation	Taddio A, Tommasini A, Valencic E, Biagi E, Decorti G, De Iudicibus S, Cuzzoni E, Gaipa G, Badolato R, Prandini A, Biondi A, Ventura A. Failure of interferon- pre-treated mesenchymal stem cell treatment in a patient with crohn’s disease. World J Gastroenterol 2015; 21(14): 4379-4384
URL	http://www.wjgnet.com/1007-9327/full/v21/i14/4379.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i14.4379

Full Article (PDF)	WJG-21-4379.pdf
Full Article (Word)	WJG-21-4379.doc
Manuscript File	13130-Review.doc
Answering Reviewers	13130-Answering reviewers.pdf
Copyright License Agreement	13130-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	13130-Language certificate.pdf
Peer-review Report	13130-Peer review(s).pdf
Scientific Misconduct Check	13130-CrossCheck.jpg
Scientific Editor Work List	13130-Scientific editor work list.pdf