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Articles Published Processes
2/11/2015 5:56:00 PM | Browse: 976 | Download: 1052
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Received |
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2014-08-07 08:23 |
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Peer-Review Started |
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2014-08-08 09:28 |
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To Make the First Decision |
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2014-09-15 16:11 |
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Return for Revision |
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2014-09-22 08:26 |
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Revised |
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2014-09-27 02:12 |
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Second Decision |
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2014-11-10 16:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-11-19 09:27 |
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Articles in Press |
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2014-11-19 09:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-27 11:01 |
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Publish the Manuscript Online |
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2015-02-11 17:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Raymond A Isidro, Myrella L Cruz, Angel A Isidro, Axel Baez, Axel Arroyo, William A González-Marqués, Carmen González-Keelan, Esther A Torres and Caroline B Appleyard |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health Grants |
U56 CA126379 (to Isidro AA and Appleyard CB) |
| National Institutes of Health Grants |
R25-GM082406 (to Isidro RA) |
| National Science Foundation: Puerto Rico Louis Stokes Alliance for Minority Participation |
0601843 (to Isidro RA) |
| PSMHS Molecular Biology Core Lab |
RR003050/MD007579 |
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| Corresponding Author |
Caroline B Appleyard, PhD, Professor, Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, PO Box 7004, Ponce, PR 00732-7004, United States. cappleyard@psm.edu |
| Key Words |
Colitis; Colon cancer; Dysplasia; Neurokinin; Vitamin D |
| Core Tip |
This study compares for the first time the expression of neurokinin-1 receptor, phosphorylated epidermal growth factor receptor, cyclooxygenase-2, and vitamin D receptor in samples from patients with sporadic colorectal neoplasia, colitis, and colitis-asso?ciated colorectal neoplasia and obtained from a Puerto Rican population. We believe that this knowledge could be of great use for the further identification of reliable markers of cancer risk and of potential therapeutic targets in a population where colorectal cancer is the deadliest cancer, and that our findings could be used in the day-to-day examination of colonic biopsies for establishing a diagnosis and distinguishing dysplasia from reactive inflammatory changes. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Isidro RA, Cruz ML, Isidro AA, Baez A, Arroyo A, González-Marqués WA, González-Keelan C, Torres EA, Appleyard CB. Immunohistochemical expression of sp-nk-1r-egfr pathway and vdr in colonic inflammation and neoplasia. World J Gastroenterol 2015; 21(6): 1749-1758 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1749.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1749 |
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