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2/9/2015 5:58:00 PM | Browse: 537 | Download: 787
Publication Name World Journal of Gastroenterology
Manuscript ID 13161
Country/Territory South Korea
Received
2014-08-11 15:27
Peer-Review Started
2014-08-11 15:36
To Make the First Decision
2014-09-15 16:11
Return for Revision
2014-09-22 08:28
Revised
2014-10-04 23:48
Second Decision
2014-11-10 16:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-19 09:31
Articles in Press
2014-11-19 09:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-26 10:18
Publish the Manuscript Online
2015-02-09 17:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients
Manuscript Source Invited Manuscript
All Author List Jeong Mo Bae, Tae Hun Lee, Nam-Yun Cho, Tae-You Kim and Gyeong Hoon Kang
Funding Agency and Grant Number
Funding Agency Grant Number
National RD Program for Cancer Control, Ministry of Health and Welfare, South Korea 0720540
Korea Healthcare Technology R and D Project, Ministry for Health, Welfare and Family Affairs, South Korea A091081
Basic Science Research Program through the National Research Foundation of Korea 2010-0007579
Mid-career Researcher Program through an NRF grant funded by the Ministry of Education, Science and Technology 2011-0015646
Corresponding author Gyeong Hoon Kang, MD, PhD, Professor, Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea. ghkang@snu.ac.kr
Keywords CDX2; CpG island methylator phenotype; Microsatellite instability; Colorectal cancer; Survival
Core Tip CDX2 is considered a tumor-suppressor gene and its expression is decreased in some colorectal cancers (CRCs). Immunohistochemical analysis of two different anti-CDX2 primary antibodies revealed that 5.9% of CRCs showed loss of CDX2 expression. Loss of CDX2 expression is associated with CpG island methylator phenotype, microsatellite instability, aggressive tumor behavior and poor clinical outcome. Patients with loss of CDX2 expression showed poor clinical outcome in univariate and multivariate survival analyses. Loss of CDX2 expression can be used as an independent prognostic marker in CRCs, especially stage Ⅳ CRCs.
Publish Date 2015-02-09 17:58
Citation Bae JM, Lee TH, Cho NY, Kim TY, Kang GH. Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients. World J Gastroenterol 2015; 21(5): 1457-1467
Url http://www.wjgnet.com/1007-9327/full/v21/i5/1457.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i5.1457
Full Article (PDF) WJG-21-1457.pdf
Full Article (Word) WJG-21-1457.doc
Manuscript File 13161-Review.doc
Answering Reviewers 13161-Answering reviewers.pdf
Copyright License Agreement 13161-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140808140101.pdf
Non-Native Speakers of English Editing Certificate 13161-Language certificate.pdf
Peer-review Report 13161-Peer review(s).pdf
Scientific Misconduct Check 13161-CrossCheck.jpg
Scientific Editor Work List 13161-Scientific editor work list.pdf