Publication Name	World Journal of Diabetes
Manuscript ID	13208
Country	Italy

Received	2014-08-12 08:28
Peer-Review Started	2014-08-12 20:10
To Make the First Decision	2014-10-14 17:54
Return for Revision	2014-10-17 09:01
Revised	2014-10-17 22:17
Second Decision	2014-11-03 17:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-03 17:20
Articles in Press	2014-11-03 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-26 17:39
Publish the Manuscript Online	2014-12-13 19:01

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Type 2 diabetes mellitus and Alzheimer’s disease
Manuscript Source	Invited Manuscript
All Author List	Mario Barbagallo and Ligia J Dominguez
Funding Agency and Grant Number
Corresponding Author	Mario Barbagallo, MD, Professor, Geriatric Unit, Department DIBIMIS, University of Palermo, Via del vespro, 129, 90127 Palermo, Italy. mario.barbagallo@unipa.it
Key Words	Dementia; Alzheimer; Type 2 diabetes; Aging; Cognitive decline; Mild cognitive impairment; Insulin; Hypoglycemia; Hyperglycemia
Core Tip	Epidemiological and biological evidences support a link between type 2 diabetes (DM2) and Alzheimer’s disease (AD). Persons with diabetes have increased incidence of cognitive decline and AD. Increased cortical and subcortical atrophy is present after controlling for vascular disease and inadequate cerebral circulation. Recent studies confirmed the role of insulin as possible link between DM2 and AD. Altered insulin signaling may contribute to AD biochemical and histopathological lesions. Hyperglycemia and hypoglycemia also have deleterious effects on cognitive function. Future trials would clarify the mechanistic link, and if cognitive decline may be prevented by an adequate metabolic control, and avoiding hypoglycemia.
Publish Date	2014-12-13 19:01
Citation	Barbagallo M, Dominguez LJ. Type 2 diabetes mellitus and Alzheimer’s disease. World J Diabetes 2014; 5(6): 889-893
URL	http://www.wjgnet.com/1948-9358/full/v5/i6/889.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i6.889

Full Article (PDF)	WJD-5-889.pdf
Full Article (Word)	WJD-5-889.doc
Manuscript File	13208-Review.doc
Answering Reviewers	13208-Answering reviewers.pdf
Copyright License Agreement	13208-Copyright assignment.pdf
Peer-review Report	13208-Peer review(s).pdf
Scientific Misconduct Check	13208-CrossCheck.jpg
Scientific Editor Work List	13208-Scientific editor work list.pdf