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4/7/2015 6:08:00 PM | Browse: 1259 | Download: 1191
Publication Name World Journal of Gastroenterology
Manuscript ID 13209
Country/Territory Italy
Received
2014-08-12 08:25
Peer-Review Started
2014-08-12 19:48
To Make the First Decision
2014-08-27 19:14
Return for Revision
2014-08-29 17:05
Revised
2014-10-04 22:16
Second Decision
2014-10-21 17:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-21 18:04
Articles in Press
2014-10-21 18:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-19 14:17
Publish the Manuscript Online
2015-04-07 17:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Urea cycle disorders: A case report of a successful treatment with liver transplant and a literature review
Manuscript Source Unsolicited Manuscript
All Author List Francesco Giuseppe Foschi, Maria Cristina Morelli, Sara Savini, Anna Chiara Dall’Aglio, Arianna Lanzi, Matteo Cescon, Giorgio Ercolani, Alessandro Cucchetti, Antonio Daniele Pinna and Giuseppe Francesco Stefanini
Funding Agency and Grant Number
Corresponding Author Francesco Giuseppe Foschi, MD, U.O. Medicina Interna, Ospedale di Faenza, Viale Stradone n°9, 48018 Faenza, Italy. fg.foschi@ausl.ra.it
Key Words Urea cycle disorders; Hyperammonemia; Diet; Liver transplantation; Quality of life
Core Tip Urea cycle disorders (UCDs) include a variety of genetic defects which lead to inefficient urea-synthesis with hyperammonemia. The liver is the main site of urea cycle’s enzymatic activity. Diet has traditionally been the primary therapy; orthotopic liver transplantation (OLT) is often considered as a last resort. This case report presents a 17-year-old girl with UCD who was successfully treated with OLT. Her recovery and a recent literature review support OLT as a primary intervention for UCDs patients to prevent life-threatening acute episodes and chronic mental impairment, with an approximately 90% survival rate and a better quality of life.
Publish Date 2015-04-07 17:13
Citation Foschi FG, Morelli MC, Savini S, Dall’Aglio AC, Lanzi A, Cescon M, Ercolani G, Cucchetti A, Pinna AD, Stefanini GF. Urea cycle disorders: A case report of a successful treatment with liver transplant and a literature review. World J Gastroenterol 2015; 21(13): 4063-4068
URL http://www.wjgnet.com/1007-9327/full/v21/i13/4063.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i13.4063
Full Article (PDF) WJG-21-4063.pdf
Full Article (Word) WJG-21-4063.doc
Manuscript File 13209-Review.doc
Answering Reviewers 13209-Answering reviewers.pdf
Copyright License Agreement 13209-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 13209-Language certificate.pdf
Peer-review Report 13209-Peer review.pdf
Scientific Misconduct Check 13209-CorssCheck.jpg
Scientific Editor Work List 13209-Scientific editor work list.pdf