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1/20/2015 9:10:00 PM | Browse: 949 | Download: 933
Publication Name World Journal of Gastroenterology
Manuscript ID 13228
Country/Territory China
Received
2014-08-13 09:01
Peer-Review Started
2014-08-13 20:16
To Make the First Decision
2014-09-15 16:15
Return for Revision
2014-09-17 22:30
Revised
2014-09-25 19:19
Second Decision
2014-10-21 17:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-21 18:03
Articles in Press
2014-10-21 18:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-11-04 21:58
Typeset the Manuscript
2015-01-06 19:16
Publish the Manuscript Online
2015-01-20 20:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title PNPLA3 I148M variant in nonalcoholic fatty liver disease: Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis
Manuscript Source Unsolicited Manuscript
All Author List Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang and Shi-Ying Xuan
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81170337/H0304
Corresponding Author Shi-Ying Xuan, PhD, Professor, Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozou Road, Qingdao 266071, Shandong Province, China. dxyxyn@163.com
Key Words PNPLA3 I148M variant; Polymorphism; Nonalcoholic fatty liver disease; Nonalcoholic fatty liver fibrosis
Core Tip In this review, we summary the association between the PNPLA3 I148M variant and nonalcoholic fatty liver disease (NAFLD), and especially its role in nonalcoholic fatty liver fibrosis. The variant is associated with NAFLD, but is predominant in women, not in men. The association may vary among different ethnic populations, but is not affected by the presence of metabolic syndrome. Then, we speculate a pro-fibrogenic network that the PNPLA3 I148M variant may promote the development of fibrogenesis by activating the Hh signaling pathway, which, in turn, leads to the activation and proliferation of hepatic stellate cells, and excessive generation and deposition of extracellular matrix.
Publish Date 2015-01-20 20:12
Citation Chen LZ, Xin YN, Geng N, Jiang M, Zhang DD, Xuan SY. PNPLA3 I148M variant in nonalcoholic fatty liver disease: Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. World J Gastroenterol 2015; 21(3): 794-802
URL http://www.wjgnet.com/1007-9327/full/v21/i3/794.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i3.794
Full Article (PDF) WJG-21-794.pdf
Full Article (Word) WJG-21-794.doc
Manuscript File 13228-Review.docx
Answering Reviewers 13228-Answering reviewers.pdf
Copyright License Agreement 13228-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 13228-Language certificate.pdf
Peer-review Report 13228-Peer reiview.pdf
Scientific Misconduct Check 13228-CorssCheck.jpg
Scientific Editor Work List 13228-Scientific editor work list.pdf