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Articles Published Processes
1/20/2015 9:10:00 PM | Browse: 1070 | Download: 1156
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Received |
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2014-08-13 09:01 |
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Peer-Review Started |
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2014-08-13 20:16 |
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To Make the First Decision |
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2014-09-15 16:15 |
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Return for Revision |
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2014-09-17 22:30 |
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Revised |
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2014-09-25 19:19 |
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Second Decision |
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2014-10-21 17:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-21 18:03 |
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Articles in Press |
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2014-10-21 18:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-11-04 21:58 |
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Typeset the Manuscript |
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2015-01-06 19:16 |
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Publish the Manuscript Online |
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2015-01-20 20:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
PNPLA3 I148M variant in nonalcoholic fatty liver disease: Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang and Shi-Ying Xuan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81170337/H0304 |
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| Corresponding Author |
Shi-Ying Xuan, PhD, Professor, Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozou Road, Qingdao 266071, Shandong Province, China. dxyxyn@163.com |
| Key Words |
PNPLA3 I148M variant; Polymorphism; Nonalcoholic fatty liver disease; Nonalcoholic fatty liver fibrosis |
| Core Tip |
In this review, we summary the association between the PNPLA3 I148M variant and nonalcoholic fatty liver disease (NAFLD), and especially its role in nonalcoholic fatty liver fibrosis. The variant is associated with NAFLD, but is predominant in women, not in men. The association may vary among different ethnic populations, but is not affected by the presence of metabolic syndrome. Then, we speculate a pro-fibrogenic network that the PNPLA3 I148M variant may promote the development of fibrogenesis by activating the Hh signaling pathway, which, in turn, leads to the activation and proliferation of hepatic stellate cells, and excessive generation and deposition of extracellular matrix. |
| Publish Date |
2015-01-20 20:12 |
| Citation |
Chen LZ, Xin YN, Geng N, Jiang M, Zhang DD, Xuan SY. PNPLA3 I148M variant in nonalcoholic fatty liver disease: Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. World J Gastroenterol 2015; 21(3): 794-802 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i3/794.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i3.794 |
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