Publication Name	World Journal of Hepatology
Manuscript ID	13252
Country	Uruguay

Received	2014-08-14 08:48
Peer-Review Started	2014-08-14 14:59
To Make the First Decision	2014-09-16 10:46
Return for Revision	2014-11-21 09:38
Revised	2014-12-22 22:57
Second Decision	2015-02-03 19:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:38
Articles in Press	2015-02-11 15:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-14 20:20
Publish the Manuscript Online	2015-05-01 19:01

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Review
Article Title	Hepatitis C virus genetic variability and evolution
Manuscript Source	Invited Manuscript
All Author List	Natalia Echeverría, Gonzalo Moratorio, Juan Cristina and Pilar Moreno
Funding Agency and Grant Number	Funding Agency Grant Number Agencia Nacional de Investigación e Innovación (ANII) through project FMV_2_2011_1_6971, Uruguay Agencia Nacional de Investigación e Innovación (ANII) through project PEDECIBA, Uruguay
Corresponding Author	Pilar Moreno, PhD, Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Mataojo 2055, 11400 Montevideo, Uruguay. pmoreno@cin.edu.uy
Key Words	Recombination; Quasispecies; Hepatitis C virus; RNA; Evolution; Antiviral therapy
Core Tip	Hepatitis C virus (HCV) is the major causative agent of parenterally-acquired hepatitis. To date there is no preventive vaccine, and though antiviral therapy has been improved in the past few years, not all patients eradicate the virus as a result of it. The main reason lies in the intrinsic genetic variability that characterises RNA viruses, such as HCV, whose RNA polymerase lacks proof-reading activity, leading to a high mutation rate and the generation of a wide range of genome variants better known as a quasispecies. Therefore this review summarises current data on HCV quasispecies dynamics, antiviral therapy and recombination events.
Publish Date	2015-05-01 19:01
Citation	Echeverría N, Moratorio G, Cristina J, Moreno P. Hepatitis C virus genetic variability and evolution. World J Hepatol 2015; 7(6): 831-845
URL	http://www.wjgnet.com/1948-5182/full/v7/i6/831.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i6.831

Full Article (PDF)	WJH-7-831.pdf
Full Article (Word)	WJH-7-831.doc
Manuscript File	13252-Review.doc
Answering Reviewers	13252-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13252-Conflict-of-interest statement.pdf
Copyright License Agreement	13252-Copyright assignment.pdf
Peer-review Report	13252-Peer-review(s).pdf
Scientific Misconduct Check	13252-Scientific misconduct check.pdf
Scientific Editor Work List	13252-Scientific editor work list.pdf