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Articles Published Processes
1/7/2015 11:06:00 AM | Browse: 1161 | Download: 1654
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Received |
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2014-08-14 08:39 |
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Peer-Review Started |
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2014-08-14 19:34 |
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To Make the First Decision |
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2014-09-15 16:15 |
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Return for Revision |
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2014-09-17 22:33 |
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Revised |
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2014-10-30 18:14 |
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Second Decision |
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2014-11-11 09:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-19 09:10 |
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Articles in Press |
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2014-11-19 09:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-11-27 14:56 |
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Typeset the Manuscript |
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2014-12-23 15:27 |
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Publish the Manuscript Online |
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2015-01-07 11:07 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Review |
Article Title |
Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics
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Manuscript Source |
Invited Manuscript |
All Author List |
Nikolaos K Gatselis, Kalliopi Zachou, George K Koukoulis and George N Dalekos |
Funding Agency and Grant Number |
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Corresponding Author |
George N Dalekos, MD, PhD, Professor, Head, Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece. georgedalekos@gmail.com |
Key Words |
Autoimmune hepatitis; Liver autoimmunity; Liver-related autoantibodies; Non-organ specific autoantibodies; Overlap syndromes |
Core Tip |
Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology. In this in-depth review we summarize the substantial progress on etiopathogenesis, clinical, serological and histological phenotypes of AIH. AIH has a global distribution affecting any age, both sexes and all ethnic groups. Clinical manifestations vary from asymptomatic to severe hepatitis. Polyclononal hypergammaglobulinemia is characteristic in most cases, while histology and autoantibodies detection are still the hallmark for timely diagnosis. Laboratory personnel, hepato-pathologists and clinicians need to become more familiar with disease expressions and the interpretation of liver histology and autoimmune serology to derive maximum benefit for the patient. |
Publish Date |
2015-01-07 11:07 |
Citation |
Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN. Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics. World J Gastroenterol 2015; 21(1): 60-83 |
URL |
http://www.wjgnet.com/1007-9327/full/v21/i1/60.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v21.i1.60 |
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