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Articles Published Processes
9/15/2014 8:54:00 PM | Browse: 1204 | Download: 886
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Received |
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2012-12-03 05:18 |
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Peer-Review Started |
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2012-12-04 15:04 |
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To Make the First Decision |
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2013-01-17 11:01 |
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Return for Revision |
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2013-01-21 14:34 |
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Revised |
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Second Decision |
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2013-04-15 16:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-04-16 07:50 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2013-06-25 04:22 |
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Typeset the Manuscript |
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2013-07-17 09:10 |
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Publish the Manuscript Online |
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2013-07-29 11:18 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Neurotensin receptor 1 overexpression in inflammatory bowel diseases and colitis-associated neoplasia
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Manuscript Source |
Invited Manuscript |
All Author List |
Xianyong Gui, Shuhong Liu, Yuchu Yan and Zuhua Gao |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Calgary Laboratory Services Internally Supported Research |
RS09-533 |
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Corresponding Author |
Xianyong Gui, MD, PhD, Calgary Laboratory Services and Department of Pathology and Laboratory Medicine, University of Calgary, 1403-29 Street NW, Calgary, Alberta T2N 2T9, Canada. xsean.gui@cls.ab.ca
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Key Words |
Neurotensin; Neurotensin receptor; Inflammatory bowel diseases; Dysplasia; Colitis-associated neoplasia; Dysplasia-associated lesion or mass; Sporadic adenoma; Colorectal carcinoma |
Core Tip |
Neurotensin receptor 1 (NTSR1) in colonic epithelial cells is overexpressed in inflammatory bowel diseases, in a stepwise fashion with the sequential progress from inflammation to low-grade dysplasia, high-grade dysplasia, and carcinoma. Both colitis-associated and sporadic dysplasia/carcinoma showed a similar pattern of NTSR1 overexpression. NTSR1 could be a potential pharmacological target in the treatment of inflammatory bowel diseases and prevention of colitis-associated neoplasia.
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Publish Date |
2013-07-29 11:18 |
Citation |
Gui X, Liu S, Yan Y, Gao Z. Neurotensin receptor 1 overexpression in inflammatory bowel diseases and colitis-associated neoplasia. World J Gastroenterol 2013; 19(28): 4504-4510 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i28/4504.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i28.4504 |
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