Publication Name	World Journal of Dermatology
Manuscript ID	13266
Country	Hungary

Received	2014-08-14 17:20
Peer-Review Started	2014-08-15 19:00
To Make the First Decision	2014-10-14 17:53
Return for Revision	2014-10-17 09:28
Revised	2014-11-12 20:34
Second Decision	2014-11-21 12:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-01 13:58
Articles in Press	2014-12-01 13:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-16 13:51
Publish the Manuscript Online	2015-01-20 11:05

ISSN	2218-6190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Dermatology
Manuscript Type	Minireviews
Article Title	Knowledge explosion for monogenic skin diseases
Manuscript Source	Invited Manuscript
All Author List	Nikoletta Nagy, Katalin Farkas, Lajos Kemény and Márta Széll
Funding Agency and Grant Number	Funding Agency Grant Number National Excellence Program TÁMOP-4.2.4.A/ 2-11/1-2012-0001 Hungarian Scientific Research Fund (OTKA) PD104782 (to Nikoletta Nagy) National Excellence Program TÁMOP-4.2.2.A-11-1-KONV-2012-0035
Corresponding Author	Dr. Nikoletta Nagy, Department of Medical Genetics, University of Szeged, 4 Somogyi Béla utca, H-6720 Szeged, Hungary. nikoletta.nagy@gmail.com
Key Words	Familial trichoepitheliomatosis; Familial cylindromatosis; Brooke-Spiegler syndrome; Monogenic skin diseases
Core Tip	Although dermatology is a morphology-orientated specialty, genetic investigation can help understand the events taking place in the skin of the affected patients. Genetic investigation of Brooke-Spiegler syndrome, familial cylindromatosis and multiple familial trichoepithelioma type 1 further supported the clinical hypothesis that these monogenic skin diseases are not different entities, but rather clinical variants of a disease spectrum caused by mutations in the cylindromatosis (CYLD) gene. In addition to understanding the underlying mechanisms of these allelic variants, genetic investigation can also accelerate the development of novel therapeutic modalities, such as therapy using tropomyosin-receptor-kinase specific lestaurtinib for patients with germline CYLD mutations.
Publish Date	2015-01-20 11:05
Citation	Nagy N, Farkas K, Kemény L, Széll M. Knowledge explosion for monogenic skin diseases. World J Dermatol 2015; 4(1): 44-49
URL	http://www.wjgnet.com/2218-6190/full/v4/i1/44.htm
DOI	http://dx.doi.org/10.5314/wjd.v4.i1.44

Full Article (PDF)	WJD-4-44.pdf
Full Article (Word)	WJD-4-44.doc
Manuscript File	13266-Review.doc
Answering Reviewers	13266-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13266-Conflict-of-interest statement.pdf
Copyright License Agreement	13266-Copyright assignment.pdf
Peer-review Report	13266-Peer review(s).pdf
Scientific Misconduct Check	13266-CrossCheck.jpg
Scientific Editor Work List	13266-Scientific editor work list.pdf