Publication Name	World Journal of Hepatology
Manuscript ID	13275
Country	United States

Received	2014-08-15 08:26
Peer-Review Started	2014-08-15 18:04
To Make the First Decision	2014-09-28 13:57
Return for Revision	2014-09-29 19:36
Revised	2014-10-24 03:59
Second Decision	2015-02-27 09:29
Accepted by Journal Editor-in-Chief	2015-02-27 21:30
Accepted by Executive Editor-in-Chief	2015-03-09 17:17
Articles in Press	2015-03-09 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-20 14:38
Publish the Manuscript Online	2015-06-03 12:00

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Methodology
Manuscript Type	Review
Article Title	Targeted proteomics for biomarker discovery and validation of hepatocellular carcinoma in hepatitis C infected patients
Manuscript Source	Invited Manuscript
All Author List	Gul M Mustafa, Denner Larry, John R Petersen and Cornelis J Elferink
Funding Agency and Grant Number
Corresponding Author	Gul M Mustafa, PhD, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0654, United States. gmmustaf@utmb.edu
Key Words	Hepatocellular carcinoma; Biomarkers; Early detection; Selected reaction monitoring; Targeted proteomics
Core Tip	The projected rise in hepatocellular carcinoma (HCC) is largely attributed to hepatitis C virus infection with onset of HCC being a latent consequence occurring decades after the original infection. However, other environmental risk factors including alcohol, tobacco, and diet-derived insults that cause liver injury increase the incidence of HCC. The poor prognosis associated with late stage diagnosis renders successful intervention difficult. The methodology described in this review article shows the feasibility of a highly multiplexed manner using multiple reaction monitoring using internal standard peptides to more easily quantify proteins, which narrows the time between discovery and validation in the biomarker pipeline in general.
Publish Date	2015-06-03 12:00
Citation	Mustafa GM, Larry D, Petersen JR, Elferink CJ. Targeted proteomics for biomarker discovery and validation of hepato­cellular carcinoma in hepatitis C infected patients. World J Hepatol 2015; 7(10): 1312-1324
URL	http://www.wjgnet.com/1948-5182/full/v7/i10/1312.htm
DOI	ttp://dx.doi.org/10.4254/wjh.v7.i10.1312

Full Article (PDF)	WJH-7-1312.pdf
Full Article (Word)	WJH-7-1312.doc
Manuscript File	13275-Review.docx
Answering Reviewers	13275-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13275-Conflict-of-interest statement.pdf
Copyright License Agreement	13275-Copyright assignment.pdf
Peer-review Report	13275-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13275-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13275-Scientific misconduct check.pdf
Scientific Editor Work List	13275-Scientific editor work list.pdf