Publication Name	World Journal of Clinical Oncology
Manuscript ID	1329
Country	Netherlands

Received	2012-12-03 16:50
Peer-Review Started	2012-12-04 15:47
To Make the First Decision	2012-12-27 11:54
Return for Revision	2012-12-28 09:32
Revised	2013-01-10 00:17
Second Decision	2013-06-06 09:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-06 12:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-20 14:54
Publish the Manuscript Online	2013-07-06 12:57

ISSN	2218-4333 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Role of E3 ubiquitin ligases in lung cancer
Manuscript Source	Invited Manuscript
All Author List	Barbara C Snoek, Leonie HAM de Wilt, Gerrit Jansen and Godefridus J Peters
Funding Agency and Grant Number
Corresponding Author	Godefridus J Peters, PhD, Department of Medical Oncology, VU University Medical Center, CCA 1.40, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. gj.peters@vumc.nl
Key Words	E3 ubiquitin ligases; Lung cancer; Ubiquitin-proteasome system; Proteasome inhibitors; Bortezomib; Apoptosis; Gene regulation; DNA repair
Core Tip	E3 ubiquitin ligases catalyze ubiquitination of proteins for degradation by the 26S proteasome. They are important for many biological processes including cell cycle regulation, proliferation and apoptosis. They are often overexpressed and deregulated in lung cancer, which contributes to cancer development. These processes underline their potential as anti-cancer targets. There is only one E3 ubiquitin ligase inhibitor in clinical trial. A better understanding of how E3 ubiquitin ligases regulate biological processes and of their exact role in carcinogenesis, will help to develop specific E3 ubiquitin ligase inhibitors to improve treatment strategies for cancer patients.
Publish Date	2013-07-06 12:57
Citation	Snoek BC, de Wilt LHAM, Jansen G, Peters GJ. Role of E3 ubiquitin ligases in lung cancer. World J Clin Oncol 2013; 4(3): 58-69
URL	http://www.wjgnet.com/2218-4333/full/v4/i3/58.htm
DOI	http://dx.doi.org/10.5306/wjco.v4.i3.58

Full Article (PDF)	WJCO-4-58.pdf
Manuscript File	1329-Review.doc
Answering Reviewers	1329-Answering reviewers.doc
Copyright License Agreement	1329-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1329-Language certificate.pdf
Peer-review Report	1329-Peer review(s).pdf
Scientific Editor Work List	1329-Scientific editor work list.doc