Publication Name	World Journal of Hepatology
Manuscript ID	13291
Country	Thailand

Received	2014-08-16 10:50
Peer-Review Started	2014-08-17 20:11
To Make the First Decision	2014-10-14 17:53
Return for Revision	2014-10-17 09:51
Revised	2014-10-27 15:21
Second Decision	2014-11-12 14:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-19 11:26
Articles in Press	2014-11-19 11:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-27 15:03
Publish the Manuscript Online	2015-02-13 09:30

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Management of patients with hepatitis C infection and renal disease
Manuscript Source	Invited Manuscript
All Author List	Chalermrat Bunchorntavakul, Monthira Maneerattanaporn and Disaya Chavalitdhamrong
Funding Agency and Grant Number
Corresponding Author	Chalermrat Bunchorntavakul, MD, Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Rajavithi Road, Ratchathewi, Bangkok 10400, Thailand. dr.chalermrat@gmail.com
Key Words	Hepatitis C; Renal disease; Chronic kidney disease; Dialysis; Interferon; Direct acting antivirals; Cryoglobulinemia
Core Tip	Hepatitis C virus (HCV) infection in patients with end-stage renal disease (ESRD) is associated with more rapid liver disease progression and reduced graft and patients’ survival following kidney transplantation. The pharmacokinetics of interferons (IFN), ribavirin (RBV) and sofosbuvir are altered in patients with ESRD. With dose adjustment and careful monitoring, treatment of HCV can be safely utilized and successful in most patients with ESRD. direct acting antiviral (DAA)-based regimens, especially IFN-/RBV-free regimens, are preferred for patients with ESRD and kidney transplantation (KT). However, due to inadequate data on clinical safety and efficacy, DAA-based therapies are not currently recommended in patients with severe renal disease. This review will be focused on evaluations and management of HCV in ESRD, KT recipients and HCV-related renal disease, according to the available treatment options including DAA.
Publish Date	2015-02-13 09:30
Citation	Bunchorntavakul C, Maneerattanaporn M, Chavalitdhamrong D. Management of patients with hepatitis C infection and renal disease. World J Hepatol 2015; 7(2): 213-225
URL	http://www.wjgnet.com/1948-5182/full/v7/i2/213.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i2.213

Full Article (PDF)	WJH-7-213.pdf
Full Article (Word)	WJH-7-213.doc
Manuscript File	13291-Review.doc
Answering Reviewers	13291-Answering reviewers.pdf
Copyright License Agreement	13291-Copyright assignment.pdf
Peer-review Report	13291-Peer review(s).pdf
Scientific Misconduct Check	13291-CrossCheck.jpg
Scientific Editor Work List	13291-Scientific editor work list.pdf