Publication Name	World Journal of Gastroenterology
Manuscript ID	13308
Country	South Korea

Received	2014-08-16 20:35
Peer-Review Started	2014-08-17 19:17
First Decision by Editorial Office Director
Return for Revision	2014-09-17 22:36
Revised	2014-10-07 09:16
Publication Fee Transferred
Second Decision by Editor	2014-11-11 10:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-11-11 10:38
Articles in Press	2014-11-11 11:09
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-21 19:22
Publish the Manuscript Online	2015-04-07 17:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Differentiation of acute and chronic hepatitis B in IgM anti-HBc positive patients
Manuscript Source	Unsolicited Manuscript
All Author List	Ji Won Park, Kyeong Min Kwak, Sung Eun Kim, Myoung Kuk Jang, Dong Joon Kim, Myung Seok Lee, Hyoung Su Kim and Choong Kee Park
Funding Agency and Grant Number	Funding Agency Grant Number Hallym University Medical Center HURF-2013-31
Corresponding Author	Hyoung Su Kim, MD, Department of Internal Medicine, Hallym University Sacred Heart Hospital of Hallym University Medical Center, 445, Gildong, Kangdong-gu, Seoul 134-701, South Korea. hskim@hallym.or.kr
Key Words	Acute hepatitis; Differential diagnosis; Chronic hepatitis; Hepatitis B virus
Core Tip	Distinguishing between acute hepatitis B (AHB) and chronic hepatitis B with acute exacerbation (CHB-AE) is important because of the different prognosis and treatment strategy. However, distinguishing AHB and CHB-AE is difficult due to their similar clinical features and serologic profiles, especially in patients with IgM anti-HBc positivity. This is the first study to differentiate between AHB and CHB-AE in a distinct group of subjects with positive IgM anti-HBc. The quantitative determination of IgM anti-HBc was useful for differentiating AHB from CHB-AE in patients IgM anti-HBc positive. The combination of serum IgM anti-HBc ≥ 8 S/CO ratio with HBV-DNA levels < 5.5 log10 IU/mL could effectively distinguish AHB from CHB-AE.
Publish Date	2015-04-07 17:13
Citation	Park JW, Kwak KM, Kim SE, Jang MK, Kim DJ, Lee MS, Kim HS, Park CK. Differentiation of acute and chronic hepatitis B in IgM anti-HBc positive patients. World J Gastroenterol 2015; 21(13): 3953-3959
URL	http://www.wjgnet.com/1007-9327/full/v21/i13/3953.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i13.3953

Full Article (PDF)	WJG-21-3953.pdf
Full Article (Word)	WJG-21-3953.doc
Manuscript File	13308-Review.doc
Answering Reviewers	13308-Answering reviewers.pdf
Copyright License Agreement	13308-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	13308-Language certificate.pdf
Peer-review Report	13308-Peer review(s).pdf
Scientific Misconduct Check	13308-CorssCheck.jpg
Scientific Editor Work List	13308-Scientific editor work list.pdf