Category |
Gastroenterology & Hepatology |
Manuscript Type |
Topic Highlights |
Article Title |
Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma
|
Manuscript Source |
Invited Manuscript |
All Author List |
Chikako Shibata, Motoyuki Otsuka, Takahiro Kishikawa, Motoko Ohno, Takeshi Yoshikawa, Akemi Takata and Kazuhiko Koike |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Ministry of Education, Culture, Sports, Science and Technology, Japan |
#25293076 (to Otsuka M) |
Ministry of Education, Culture, Sports, Science and Technology, Japan |
#26860492 (to Kishikawa T) |
Ministry of Education, Culture, Sports, Science and Technology, Japan |
#25860520 (to Yoshikawa T) |
Ministry of Education, Culture, Sports, Science and Technology, Japan |
#24390183 (to Koike K) |
Health Sciences Research Grants of The Ministry of Health, Labour and Welfare of Japan |
to Koike K |
Japanese Society of Gastroenterology, Okinaka Memorial Institute for Medical Research, and Honjo International Scholarship Foundation |
to Otsuka M |
Mishima Kaiun Memorial Foundation |
to Ohno M |
|
Corresponding Author |
Motoyuki Otsuka, MD, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 5-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655,
Japan. otsukamo-tky@umin.ac.jp
|
Key Words |
MicroRNA; Long noncoding RNA; Hepatocellular carcinoma; Clinical trials; Biomarker |
Core Tip |
In this review, we summarize the latest findings on deregulated microRNAs (miRNAs) and long noncoding RNAs in hepatocellular carcinomas (HCCs) with a focus on their clinical use as novel diagnostic and prognostic biomarkers. In addition, we summarize the current status of clinical and preclinical oligonucleotide therapies including miRNAs and small interfering RNAs as novel HCC therapeutics. This review will enable the readers to understand the current status of clinical applications and knowledge of noncoding RNAs in HCC management.
|
Publish Date |
2015-01-10 16:31 |
Citation |
Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K. Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma. World J Hepatol 2015; 7(1): 1-6 |
URL |
http://www.wjgnet.com/1948-5182/full/v7/i1/1.htm |
DOI |
http://dx.doi.org/10.4254/wjh.v7.i1.1 |