Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	13366
Country	United States

Received	2014-08-20 08:25
Peer-Review Started	2014-08-20 10:59
To Make the First Decision	2014-09-16 11:07
Return for Revision	2014-09-20 21:22
Revised	2014-09-24 23:10
Second Decision	2015-01-14 09:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-01-20 16:35
Articles in Press	2015-01-20 16:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-13 14:17
Publish the Manuscript Online	2015-04-19 16:12

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Biomarkers in bile-complementing advanced endoscopic imaging in the diagnosis of indeterminate biliary strictures
Manuscript Source	Invited Manuscript
All Author List	Vennisvasanth Lourdusamy, Benjamin Tharian and Udayakumar Navaneethan
Funding Agency and Grant Number
Corresponding Author	Udayakumar Navaneethan, MD, FACP, Center for Interventional Endoscopy, Institute for Minimally Invasive Surgery, Florida Hospital, 601 E Rollins Street, Orlando, FL 32803, United States. udhaykumar81@gmail.com
Key Words	Bile; Pancreato-biliary malignancies; Biomarkers; Cholangiocarcinoma; Pancreatic cancers; Biliary strictures
Core Tip	Pancreato-biliary malignancies remain a dia-g-nostic challenge despite advances in endoscopy and imaging. Serum carbohydrate antigen 19-9 which is the most commonly used tumor marker has not been able to complement the endoscopic techniques effectively. Bile fluid is a better representative of the pancreato-biliary malignancies and various tumor markers in bile have been described recently with advances in proteomics. Carcinoembryonic cell adhesion molecule 6, neutrophil gelatinase-associated lipocalin and other novel biliary markers seem promising with high sensitivities and specificities, little affected by the presence of inflammation or the degree of biliary obstruction. These are potential future tumor markers that can complement endoscopic techniques in diag-nosing malignant biliary strictures.
Publish Date	2015-04-19 16:12
Citation	Lourdusamy V, Tharian B, Navaneethan U. Biomarkers in bile-complementing advanced endoscopic imaging in the diagnosis of indeterminate biliary strictures. World J Gastrointest Endosc 2015; 7(4): 308-317
URL	http://www.wjgnet.com/1948-5190/full/v7/i4/308.htm
DOI	http://dx.doi.org/10.4253/wjge.v7.i4.308

Full Article (PDF)	WJGE-7-308.pdf
Full Article (Word)	WJGE-7-308.doc
Manuscript File	13366-Review.doc
Answering Reviewers	13366-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13366-Conflict-of-interest statement.pdf
Copyright License Agreement	13366-Copyright assignment.pdf
Peer-review Report	13366-Peer review(s).pdf
Scientific Misconduct Check	13366-CrossCheck.jpg
Scientific Editor Work List	13366-Scientific editor work list.pdf