Publication Name	World Journal of Hepatology
Manuscript ID	13381
Country	Japan

Received	2014-08-21 08:56
Peer-Review Started	2014-08-22 08:23
To Make the First Decision	2014-12-17 11:21
Return for Revision	2014-12-19 11:28
Revised	2014-12-19 18:48
Second Decision	2015-01-22 20:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-02 20:07
Articles in Press	2015-02-02 20:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-28 16:53
Publish the Manuscript Online	2015-05-19 17:28

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Natural interferon-beta treatment for patients with chronic hepatitis C in Japan
Manuscript Source	Invited Manuscript
All Author List	Reina Sasaki, Tatsuo Kanda, Shingo Nakamoto, Yuki Haga, Masato Nakamura, Shin Yasui, Xia Jiang, Shuang Wu, Makoto Arai and Osamu Yokosuka
Funding Agency and Grant Number
Corresponding Author	Tatsuo Kanda, MD, PhD, Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. kandat-cib@umin.ac.jp
Key Words	Hepatocellular carcinoma; Hepatitis C virus; Interferon-beta; Interferon resistance; Ribavirin
Core Tip	The use of natural interferon-beta plus ribavirin can eradicate hepatitis C virus (HCV) from non-responders to peginterferon-alpha plus ribavirin treatment. Some of these patients may have anti-interferon-alpha neutralizing antibodies. In Japan, natural interferon-beta plus ribavirin has been used for certain “difficult-to-treat” HCV-infected patients such as elderly patients, patients with mental disorders and patients with lower platelet counts, before the era of interferon-free regimens. To eradicate hepatocellular carcinoma and end-stage liver diseases associated with HCV, the use of natural interferon-beta with or without ribavirin should be one of the useful treatment options for HCV-infected patients.
Publish Date	2015-05-19 17:28
Citation	Sasaki R, Kanda T, Nakamoto S, Haga Y, Nakamura M, Yasui S, Jiang X, Wu S, Arai M, Yokosuka O. Natural interferon-beta treatment for patients with chronic hepatitis C in Japan. World J Hepatol 2015; 7(8): 1125-1132
URL	http://www.wjgnet.com/1948-5182/full/v7/i8/1125.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i8.1125

Full Article (PDF)	WJH-7-1125.pdf
Full Article (Word)	WJH-7-1125.doc
Manuscript File	13381-Review.doc
Answering Reviewers	13381-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13381-Conflict-of-interest statement.pdf
Copyright License Agreement	13381-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	13381-Language certificate.pdf
Peer-review Report	13381-Peer-review(s).pdf
Scientific Misconduct Check	13381-CrossCheck.jpg
Scientific Editor Work List	13381-Scientific editor work list.pdf