Publication Name	World Journal of Diabetes
Manuscript ID	13384
Country	Japan

Received	2014-08-21 08:50
Peer-Review Started	2014-08-21 11:32
To Make the First Decision	2014-09-16 11:06
Return for Revision	2014-09-20 21:03
Revised	2014-10-07 22:41
Second Decision
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-10 16:09
Articles in Press	2014-11-10 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-26 11:44
Publish the Manuscript Online	2014-12-13 19:01

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Nonalcoholic steatohepatitis and insulin resistance in children
Manuscript Source	Invited Manuscript
All Author List	Mikage Arata, Junya Nakajima, Shigeo Nishimata, Tomomi Nagata and Hisashi Kawashima
Funding Agency and Grant Number
Corresponding Author	Hisashi Kawashima, MD, PhD, Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. hisashi@tokyo-med.ac.jp
Key Words	Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Insulin resistance; Homeostasis model assessment as an index of insulin resistance; Obesity
Core Tip	The pathological characteristics of nonalcoholic steatohepatitis (NASH) are significantly different between children and adults. Nonalcoholic fatty liver disease is accompanied by insulin resistance, which plays a pivotal role in its pathophysiology in both adults and children. In NASH, a “two-hit” model involving triglyceride accumulation (first hit) and liver damage (second hit) has been accepted. Insulin resistance was found to correlate with changes in fat levels; however, it did not correlate with fibrosis in children. Insulin resistance may be important in the first hit. Genetic predisposition as well as environmental factors might be the second hit in children.
Publish Date	2014-12-13 19:01
Citation	Arata M, Nakajima J, Nishimata S, Nagata T, Kawashima H. Nonalcoholic steatohepatitis and insulin resistance in children. World J Diabetes 2014; 5(6): 917-923
URL	http://www.wjgnet.com/1948-9358/full/v5/i6/917.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i6.917

Full Article (PDF)	WJD-5-917.pdf
Full Article (Word)	WJD-5-917.doc
Manuscript File	13384-Review.docx
Answering Reviewers	13384-Answering reviewers.pdf
Copyright License Agreement	13384-Copyright assignment.pdf
Peer-review Report	13384-Peer review(s).pdf
Scientific Misconduct Check	13384-CrossCheck.jpg
Scientific Editor Work List	13384-Scientific editor work list.pdf