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Articles Published Processes
12/13/2014 7:02:00 PM | Browse: 987 | Download: 1522
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Received |
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2014-08-21 08:50 |
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Peer-Review Started |
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2014-08-21 11:32 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-09-20 21:03 |
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Revised |
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2014-10-07 22:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-11-10 16:09 |
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Articles in Press |
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2014-11-10 16:09 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-26 11:44 |
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Publish the Manuscript Online |
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2014-12-13 19:01 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Nonalcoholic steatohepatitis and insulin resistance in children
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mikage Arata, Junya Nakajima, Shigeo Nishimata, Tomomi Nagata and Hisashi Kawashima |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hisashi Kawashima, MD, PhD, Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023,
Japan. hisashi@tokyo-med.ac.jp
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| Key Words |
Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Insulin resistance; Homeostasis model assessment as an index of insulin resistance; Obesity |
| Core Tip |
The pathological characteristics of nonalcoholic steatohepatitis (NASH) are significantly different between children and adults. Nonalcoholic fatty liver disease is accompanied by insulin resistance, which plays a pivotal role in its pathophysiology in both adults and children. In NASH, a “two-hit” model involving triglyceride accumulation (first hit) and liver damage (second hit) has been accepted. Insulin resistance was found to correlate with changes in fat levels; however, it did not correlate with fibrosis in children. Insulin resistance may be important in the first hit. Genetic predisposition as well as environmental factors might be the second hit in children.
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| Publish Date |
2014-12-13 19:01 |
| Citation |
Arata M, Nakajima J, Nishimata S, Nagata T, Kawashima H. Nonalcoholic steatohepatitis and insulin resistance in children. World J Diabetes 2014; 5(6): 917-923
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| URL |
http://www.wjgnet.com/1948-9358/full/v5/i6/917.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v5.i6.917 |
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