Publication Name	World Journal of Gastroenterology
Manuscript ID	13397
Country	China

Received	2014-08-21 08:09
Peer-Review Started	2014-08-21 16:21
To Make the First Decision	2014-09-27 14:24
Return for Revision	2014-10-11 10:28
Revised	2014-10-28 20:45
Second Decision	2014-11-27 13:19
Accepted by Journal Editor-in-Chief	2014-11-29 04:30
Accepted by Executive Editor-in-Chief	2014-12-08 16:11
Articles in Press	2014-12-08 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-12-14 18:05
Typeset the Manuscript	2015-04-13 17:32
Publish the Manuscript Online	2015-04-27 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Genetics & Heredity
Manuscript Type	Meta-Analysis
Article Title	Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Zhi-Jun Dai, Yong-Ping Shao, Hua-Feng Kang, Wei Tang, Dan Xu, Yang Zhao, Di Liu, Meng Wang, Peng-Tao Yang and Xi-Jing Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81471670 National Natural Science Foundation of China 81102711 International Cooperative Project of Shaanxi Province, China 2013KW-32-01 Fundamental Research Funds for the Central Universities, China Specialized Research Fund of the Second Affiliated Hospital of Xi'an Jiaotong University, China RC (GG) 201203
Corresponding Author	hi-Jun Dai, MD, PhD, Department of Oncology, the Second Affiliated Hospital of Xi’an Jiaotong University, No. 157, West 5th Road, Xi’an 710004, Shaanxi Province, China. dzj0911@126.com
Key Words	Apurinic endonuclease 1; Single nucleotide polymorphism; Gastrointestinal cancers; Cancer risk; Meta-analysis
Core Tip	Apurinic endonuclease 1 (APE1) plays an important role in the DNA repair system and therefore has been implicated in human carcinogenesis. Many studies have suggested an association between the APE1 Asp148Glu polymorphism and gastrointestinal cancer susceptibility. However, the results remained inconclusive. We performed a meta-analysis on pooled data from previously published studies. The results showed that the APE1 Asp148Glu polymorphism G allele is associated with an increased gastrointestinal cancer risk, especially in gastric cancer.
Publish Date	2015-04-27 16:22
Citation	Dai ZJ, Shao YP, Kang HF, Tang W, Xu D, Zhao Y, Liu D, Wang M, Yang PT, Wang XJ. Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis. World J Gastroenterol 2015; 21(16): 5081-5089
URL	http://www.wjgnet.com/1007-9327/full/v21/i16/5081.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i16.5081

Full Article (PDF)	WJG-21-5081.pdf
Full Article (Word)	WJG-21-5081.doc
Manuscript File	13397-Review.doc
Answering Reviewers	13397-Answering reviewers.pdf
Copyright License Agreement	13397-Copyright assignment.pdf
Peer-review Report	13397-Peer review(s).pdf
Scientific Misconduct Check	13397-CrossCheck.jpg
Scientific Editor Work List	13397-Scientific editor work list.pdf