Publication Name	World Journal of Stem Cells
Manuscript ID	13411
Country	Switzerland

Received	2014-08-22 08:51
Peer-Review Started	2014-08-22 11:45
To Make the First Decision	2014-09-04 09:29
Return for Revision	2014-09-06 16:06
Revised	2014-10-30 00:00
Second Decision	2014-11-21 17:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-01 13:49
Articles in Press	2014-12-01 13:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-25 16:43
Publish the Manuscript Online	2015-03-20 10:47

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Mesenchymal stem cells and collagen patches for anterior cruciate ligament repair
Manuscript Source	Invited Manuscript
All Author List	Benjamin Gantenbein, Neha Gadhari, Samantha CW Chan, Sandro Kohl and Sufian S Ahmad
Funding Agency and Grant Number
Corresponding Author	Dr. Benjamin Gantenbein, Professor, Tissue and Organ Mechanobiology, Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, CH-3014 Bern, Switzerland. benjamin.gantenbein@istb.unibe.ch
Key Words	Anterior cruciate ligament rupture; Anterior cruciate ligament tenocyte; Dynamic intraligamentary stabilization system; Resazurin red assay; Mesenchymal stem cells; Real-time polymerase chain reaction; Histology; Scanning electron microscopy microscopy; Scanning electron microscopy
Core Tip	Commercially available porcine or bovine-derived collagen type Ⅰ and type Ⅲ patches are cytocompatible for anterior cruciate ligament derived tenocytes (ACL-TCs) and for bone-marrow derived mesenchymal stem cells (MSCs). The combination of commercially available collagen patches with MSCs and ACL-TCs seems to be suitable for application with a dynamic intraligamentary stabilization system, which represents a novel technique to fix a ruptured ACL. However, co-culture of MSCs with ACL-TCs did show signs of differentiation of MSCs towards a more TC-like phenotype after a short-term culture of 7 d.
Publish Date	2015-03-20 10:47
Citation	Gantenbein B, Gadhari N, Chan SCW, Kohl S, Ahmad SS. Mesenchymal stem cells and collagen patches for anterior cruciate ligament repair. World J Stem Cells 2015; 7(2): 521-534
URL	http://www.wjgnet.com/1948-0210/full/v7/i2/521.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i2.521

Full Article (PDF)	WJSC-7-521.pdf
Full Article (Word)	WJSC-7-521.doc
Manuscript File	13411-Review.docx
Answering Reviewers	13411-Answering reviewers.pdf
Biostatistics Review Certificate	13411-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	13411-Conflict-of-interest statement.pdf
Copyright License Agreement	13411-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	13411-Institutional review board statement.pdf
Peer-review Report	13411-Peer review(s).pdf
Scientific Misconduct Check	13411-CrossCheck.jpg
Scientific Editor Work List	13411-Scientific editor work list.pdf