Publication Name	World Journal of Critical Care Medicine
Manuscript ID	13416
Country	Japan

Received	2014-08-22 08:34
Peer-Review Started	2014-08-22 14:45
To Make the First Decision	2014-09-28 13:45
Return for Revision	2014-10-05 19:04
Revised	2015-02-05 00:41
Second Decision	2015-04-20 11:31
Accepted by Journal Editor-in-Chief	2015-04-21 02:19
Accepted by Company Editor-in-Chief	2015-04-29 15:23
Articles in Press	2015-04-29 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-27 17:08
Publish the Manuscript Online	2015-08-17 18:00

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Clinical Trials Study
Article Title	Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis
Manuscript Source	Unsolicited Manuscript
All Author List	Masaki Okajima, Masayuki Takamura and Takumi Taniguchi
Funding Agency and Grant Number
Corresponding Author	Masaki Okajima, MD, PhD, Intensive Care Unit, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa 920-8641, Japan. masaki46228@m-kanazawa.jp
Key Words	Landiolol; Supraventricular tachyarrhy­thmias; Sepsis; Rate control; Conversion to sinus rhythm
Core Tip	The management of tachyarrhythmia is important but it is often difficult because of unstable hemodynamics in septic patients. Landiolol is an ultra-short-acting β1 selective adrenoceptor antagonist. It exerts a more potent negative chronotropic effect and a lesser effect on blood pressure than other β blockers. In fact, landiolol significantly reduced heart rate without any deterioration of hemodynamics in this study. The most impressive finding is high conversion rate to sinus rhythm immediately after landiolol administration. Landiolol could control not only heart rate but also cardiac rhythm in septic patients with supraventricular tachyarrhythmias. Landiolol safely reduced heart rate and, in part, converted to sinus rhythm in septic patients with supraventricular tachyarrhythmia. Landiolol could be a valuable and suitable drug for managing supraventricular tachyarrhythmias in patients with sepsis.
Publish Date	2015-08-17 18:00
Citation	Okajima M, Takamura M, Taniguchi T. Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis. World J Crit Care Med 2015; 4(3): 251-257
URL	http://www.wjgnet.com/2220-3141/full/v4/i3/251.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i3.251

Full Article (PDF)	WJCCM-4-251.pdf
Full Article (Word)	WJCCM-4-251.doc
Manuscript File	13416-Review.doc
Answering Reviewers	13416-Answering reviewers.pdf
Audio Core Tip	13416-Audio core tip.mp3
Biostatistics Review Certificate	13416-Biostatistics statement.pdf
Clinical Trial Registration Statement	13416-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	13416-Conflict-of-interest statement.pdf
Copyright License Agreement	13416-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	13416-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	13416-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	13416-Language certificate.pdf
Peer-review Report	13416-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13416-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13416-Scientific misconduct check.pdf
Scientific Editor Work List	13416-Scientific editor work list.pdf