Publication Name	World Journal of Stem Cells
Manuscript ID	13423
Country	Japan

Received	2014-08-22 11:11
Peer-Review Started	2014-08-23 09:54
To Make the First Decision	2014-09-28 13:44
Return for Revision	2014-10-05 17:49
Revised	2015-01-15 10:08
Second Decision	2015-06-09 13:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-17 14:10
Articles in Press	2015-07-17 14:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-15 21:50
Publish the Manuscript Online	2015-08-27 10:51

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Minireviews
Article Title	Rat embryonic stem cells create new era in development of genetically manipulated rat models
Manuscript Source	Invited Manuscript
All Author List	Kazushi Kawaharada, Masaki Kawamata and Takahiro Ochiya
Funding Agency and Grant Number
Corresponding Author	Dr. Takahiro Ochiya, Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. tochiya@ncc.go.jp
Key Words	Embryonic stem cells; Transgenic rat
Core Tip	Rat embryonic stem (ES) cells are thought to be an essential tool for creating transgenic rats. Since the method for establishing rat ES cells using signaling inhibitors was reported, numerous approaches have been made to propagate rat ES cells efficiently. Additionally, recent investigations have demonstrated the usefulness of the signal inhibitors for microinjection. In this review, we summarize the several advanced methods to maintain rat ES cells and generate gene-targeted rats.
Publish Date	2015-08-27 10:51
Citation	Kawaharada K, Kawamata M, Ochiya T. Rat embryonic stem cells create new era in development of genetically manipulated rat models. World J Stem Cells 2015; 7(7): 1054-1063
URL	http://www.wjgnet.com/1948-0210/full/v7/i7/1054.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i7.1054

Full Article (PDF)	WJSC-7-1054.pdf
Full Article (Word)	WJSC-7-1054.doc
Manuscript File	13423-Review.doc
Answering Reviewers	13423-Answering reviewers.pdf
Audio Core Tip	13423-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	13423-Conflict-of-interest statement.pdf
Copyright License Agreement	13423-Copyright assignment.pdf
Peer-review Report	13423-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13423-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13423-Scientific misconduct check.pdf
Scientific Editor Work List	13423-Scientific editor work list.pdf