Publication Name	World Journal of Orthopedics
Manuscript ID	1346
Country	Australia

Received	2012-12-04 11:03
Peer-Review Started	2012-12-04 19:31
To Make the First Decision	2012-12-27 11:58
Return for Revision	2012-12-27 17:44
Revised	2013-01-07 08:17
Second Decision	2013-03-22 11:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-03-23 09:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-16 12:24
Publish the Manuscript Online	2013-10-28 15:24

ISSN	2218-5836 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Topic Highlights
Article Title	Historically significant events in the discovery of RANK/RANKL/OPG
Manuscript Source	Invited Manuscript
All Author List	T John Martin
Funding Agency and Grant Number	Funding Agency Grant Number National Health and Medical Research Council Victorian Government OIS Program
Corresponding Author	Dr. T John Martin, Department of Medicine and St Vincent’s Institute of Medical Research, University of Melbourne, 9 Princes Street, Fitzroy 3065, Victoria, Australia. jmartin@svi.edu.au
Key Words	Receptor activator of nuclear factor B ligand; Osteoprotegerin; Receptor activator of nuclear factor B; Osteoclasts; Bone biology
Core Tip	The history of discovery of receptor activator of nuclear factor ?B ligand began with the hypothesis that the osteoblast lineage controls osteoclast formation. The hypothesis was confirmed by experiments showing first, that osteoblastic cells were necessary for osteoclast activation, then some years later that osteoblasts were necessary for osteoclast formation in a contact-dependent process. Ultimate confirmation came from mouse genetics, discovering inhibition of osteoblast formation by a secreted tumor necrosis factor (TNF) ligand, followed by discovery of promotion of osteoclast formation by a membrane-bound member of the TNF ligand family that signalled through its receptor in hemopoietic cells to promote osteoclast formation.
Publish Date	2013-10-28 15:24
Citation	Martin TJ. Historically significant events in the discovery of RANK/RANKL/OPG. World J Orthop 2013; 4(4): 186-197
URL	http://www.wjgnet.com/2218-5836/full/v4/i4/186.htm
DOI	http://dx.doi.org/10.5312/wjo.v4.i4.186

Full Article (PDF)	WJO-4-186.pdf
Manuscript File	1346-Review.doc
Answering Reviewers	1346-Answering reviewers.doc
Copyright License Agreement	1346-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	1346-Language cetificate.doc
Peer-review Report	1346-Peer review.pdf
Scientific Editor Work List	1346-Scientific editor work list.doc