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Publication Name World Journal of Orthopedics
Manuscript ID 1346
Country/Territory Australia
2012-12-04 11:03
Peer-Review Started
2012-12-04 19:31
To Make the First Decision
2012-12-27 11:58
Return for Revision
2012-12-27 17:44
2013-01-07 08:17
Second Decision
2013-03-22 11:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-03-23 09:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-16 12:24
Publish the Manuscript Online
2013-10-28 15:24
ISSN 2218-5836 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Topic Highlights
Article Title Historically significant events in the discovery of RANK/RANKL/OPG
Manuscript Source Invited Manuscript
All Author List T John Martin
Funding Agency and Grant Number
Funding Agency Grant Number
National Health and Medical Research Council
Victorian Government OIS Program
Corresponding author Dr. T John Martin, Department of Medicine and St Vincent’s Institute of Medical Research, University of Melbourne, 9 Princes Street, Fitzroy 3065, Victoria, Australia. jmartin@svi.edu.au
Keywords Receptor activator of nuclear factor B ligand; Osteoprotegerin; Receptor activator of nuclear factor B; Osteoclasts; Bone biology
Core Tip The history of discovery of receptor activator of nuclear factor ?B ligand began with the hypothesis that the osteoblast lineage controls osteoclast formation. The hypothesis was confirmed by experiments showing first, that osteoblastic cells were necessary for osteoclast activation, then some years later that osteoblasts were necessary for osteoclast formation in a contact-dependent process. Ultimate confirmation came from mouse genetics, discovering inhibition of osteoblast formation by a secreted tumor necrosis factor (TNF) ligand, followed by discovery of promotion of osteoclast formation by a membrane-bound member of the TNF ligand family that signalled through its receptor in hemopoietic cells to promote osteoclast formation.
Publish Date 2013-10-28 15:24
Citation Martin TJ. Historically significant events in the discovery of RANK/RANKL/OPG. World J Orthop 2013; 4(4): 186-197
Url http://www.wjgnet.com/2218-5836/full/v4/i4/186.htm
DOI http://dx.doi.org/10.5312/wjo.v4.i4.186
Full Article (PDF) WJO-4-186.pdf
Manuscript File 1346-Review.doc
Answering Reviewers 1346-Answering reviewers.doc
Copyright License Agreement 1346-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate 1346-Language cetificate.doc
Peer-review Report 1346-Peer review.pdf
Scientific Editor Work List 1346-Scientific editor work list.doc