Publication Name	World Journal of Hepatology
Manuscript ID	13471
Country	Japan

Received	2014-08-24 15:24
Peer-Review Started	2014-08-24 18:27
To Make the First Decision	2014-09-16 11:02
Return for Revision	2014-09-19 10:13
Revised	2014-09-30 21:20
Second Decision	2015-04-01 15:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-14 16:34
Articles in Press	2015-04-14 16:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-24 17:55
Publish the Manuscript Online	2015-07-10 17:51

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Relevance of ADAMTS13 to liver transplantation and surgery
Manuscript Source	Invited Manuscript
All Author List	Saiho Ko, Hisanao Chisuwa, Masanori Matsumoto, Yoshihiro Fujimura, Eiji Okano and Yoshiyuki Nakajima
Funding Agency and Grant Number
Corresponding Author	Saiho Ko, Director, Departement of Surgery, Nara Prefecture General Medical Center, 1-30-1 Hiramatsu, Nara-city, Nara 631-0846, Japan. saihoko@naramed-u.ac.jp
Key Words	A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13; Thrombocytopenia; Microcirculation; Liver dysfunction; von Willebrand factor; Liver transplantation; Acute rejection; Ischemia-reperfusion injury; Hepatectomy; Liver surgery; Local thrombotic thrombocytopenic purpura like mechanism
Core Tip	A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) is a cleaving protease of von Willebrand factor (VWF). The deficiency of this molecule is known to cause thrombotic thrombocytopenic purpura (TTP). Recent studies revealed that ADAMTS13 might have functional relevance to pathogenesis of various liver disease separately from the development of TTP. Imbalance between ADAMTS13 and VWF in the hepatic sinusoid might cause liver damage due to microcirculatory disturbance. It can be called as “local TTP like mechanism” which plays a crucial role in liver dysfunction after liver transplantation and surgery including ischemia reperfusion injury and acute rejection.
Publish Date	2015-07-10 17:51
Citation	Ko S, Chisuwa H, Matsumoto M, Fujimura Y, Okano E, Nakajima Y. Relevance of ADAMTS13 to liver transplantation and surgery. World J Hepatol 2015; 7(13): 1772-1781
URL	http://www.wjgnet.com/1948-5182/full/v7/i13/1772.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i13.1772

Full Article (PDF)	WJH-7-1772.pdf
Full Article (Word)	WJH-7-1772.doc
Manuscript File	13471-Review.docx
Answering Reviewers	13471-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13471-Conflict-of-interest statement.pdf
Copyright License Agreement	13471-Copyright assignment.pdf
Peer-review Report	13471-Peer-review(s).pdf
Scientific Misconduct Check	13471-Scientific misconduct check.pdf
Scientific Editor Work List	13471-Scientific editor work list.pdf