Publication Name	World Journal of Experimental Medicine
Manuscript ID	13487
Country	Netherlands

Received	2014-08-25 17:45
Peer-Review Started	2014-08-26 17:06
To Make the First Decision	2014-10-14 18:11
Return for Revision	2014-10-20 12:12
Revised	2014-10-31 15:12
Second Decision	2015-01-29 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-02-09 10:39
Articles in Press	2015-02-09 10:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-22 16:05
Publish the Manuscript Online	2015-05-21 14:15

ISSN	2220-315x (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Clinical Trials Study
Article Title	Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration
Manuscript Source	Invited Manuscript
All Author List	Anabel S de la Garza-Rodea, Hester Boersma, Cheryl Dambrot, Antoine AF de Vries, Dirk W van Bekkum and Shoshan Knaän-Shanzer
Funding Agency and Grant Number	Funding Agency Grant Number Universidad Autonoma de Nuevo Leon, Monterrey, Mexico to AS de la Garza-Rodea
Corresponding Author	Dr. Shoshan Knaän-Shanzer, Virus and Stem Cell Biology Laboratory, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, the Netherlands. shoshanknaan@gmail.com
Key Words	Skeletal muscle; Muscle regeneration; Muscle implants; Mesenchymal stem cells; Satellite cells
Core Tip	The translational relevance of animal models for tissue repair is often ambiguous. We describe here a murine model for the comparison of the regeneration of damaged human and murine skeletal muscle implants and the contribution of human and mouse mesenchymal stem cells (MSCs) to this process. Our findings suggest that murine muscle tissue provides a suboptimal environment for maintenance of human MSC, and that in mouse models their capacity to engage in myoregeneration is underestimated. The added value of the present model is that it permits the dissection of species-specific factors in the microenvironment.
Publish Date	2015-05-21 14:15
Citation	de la Garza-Rodea AS, Boersma H, Dambrot C, de Vries AAF, van Bekkum DW, Knaän-Shanzer S. Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration. World J Exp Med 2015; 5(2): 140-153
URL	http://www.wjgnet.com/2220-315X/full/v5/i2/140.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i2.140

Full Article (PDF)	WJEM-5-140.pdf
Full Article (Word)	WJEM-5-140.doc
Manuscript File	13487-Review.doc
Answering Reviewers	13487-Answering reviewers.pdf
Copyright License Agreement	13487-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	13487-Institutional review board statement.pdf
Peer-review Report	13487-Peer-review(s).pdf
Scientific Misconduct Check	13487-Scientific misconduct check.pdf
Scientific Editor Work List	13487-Scientific editor work list.pdf