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4/15/2015 11:01:00 AM | Browse: 1037 | Download: 2037
Publication Name World Journal of Gastroenterology
Manuscript ID 13496
Country/Territory China
Received
2014-08-25 16:55
Peer-Review Started
2014-08-26 14:24
To Make the First Decision
2014-09-27 16:01
Return for Revision
2014-10-10 13:47
Revised
2014-11-19 14:43
Second Decision
2014-12-26 13:41
Accepted by Journal Editor-in-Chief
2014-12-27 10:14
Accepted by Company Editor-in-Chief
2015-01-08 17:20
Articles in Press
2015-01-08 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-01-22 23:11
Typeset the Manuscript
2015-03-31 19:48
Publish the Manuscript Online
2015-04-15 11:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Prospective Study
Article Title Prophylactic antiviral therapy in allogeneic hematopoietic stem cell transplantation in hepatitis B virus patients
Manuscript Source Unsolicited Manuscript
All Author List Ya-Ping Liao, Jia-Lu Jiang, Wai-Yi Zou, Duo-Rong Xu and Juan Li
Funding Agency and Grant Number
Corresponding Author Wai-Yi Zou, Associate Professor, Department of Hematology, the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. waiyizou@medmail.com.cn
Key Words Hematopoietic stem cell transplantation; Hepatitis B virus; Antiviral therapy; Nucleotide analogues
Core Tip The threshold of pre-transplantation hepatitis B virus (HBV) DNA for allo-HSCT was defined as 103 IU/mL. Only 1 patient developed HBV reactivation due to early discontinuation of antiviral therapy. The hepatitis B surface antigen (HBsAg)(+), HBsAg(-)/hepatitis B core antibody(+) and non-HBV infected groups showed no statistically significant differences in the incidence of graft-vs-host disease, drug-induced liver injury, hepatic veno-occlusive disease death, survival times and post-transplantation cumulative survival rates. In summary, suppression of HBV DNA to < 103 IU/mL before transplantation, continued antiviral therapy and close monitoring of immune markers of hepatitis B and HBV DNA after trans plantation may assure the safety of allogeneic hematopoietic stem cell transplantation.
Publish Date 2015-04-15 11:01
Citation Liao YP, Jiang JL, Zou WY, Xu DR, Li J. Prophylactic antiviral therapy in allogeneic hematopoietic stem cell transplantation in hepatitis B virus patients. World J Gastroenterol 2015; 21(14): 4284-4292
URL http://www.wjgnet.com/1007-9327/full/v21/i14/4284.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i14.4284
Full Article (PDF) WJG-21-4284.pdf
Full Article (Word) WJG-21-4284.doc
Manuscript File 13496-Review.doc
Answering Reviewers 13496-Answering reviewers.pdf
Biostatistics Review Certificate 13496-Biostatistics statement.pdf
Clinical Trial Registration Statement 13496-Clinical trial registration.pdf
Conflict-of-Interest Disclosure Form 13496-Conflict-of-interest statement.pdf
Copyright License Agreement 13496-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 13496-Clinical trial registration.pdf
Institutional Review Board Approval Form or Document 13496-Institutional Review Board (IRB) statement.pdf
Non-Native Speakers of English Editing Certificate 13496-Language certificate.pdf
Peer-review Report 13496-Peer review(s).pdf
Scientific Misconduct Check 13496-CorssCheck.jpg
Scientific Editor Work List 13496-Scientific editor work list.pdf