Publication Name	World Journal of Diabetes
Manuscript ID	13497
Country	Japan

Received	2014-08-25 16:53
Peer-Review Started	2014-08-25 17:40
To Make the First Decision	2014-12-17 11:39
Return for Revision	2014-12-19 08:49
Revised	2014-12-24 15:25
Second Decision	2015-01-28 12:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-09 09:33
Articles in Press	2015-02-09 09:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-08 10:04
Publish the Manuscript Online	2015-04-20 09:13

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Interplay between Rab27a effectors in pancreatic β-cells
Manuscript Source	Invited Manuscript
All Author List	Mami Yamaoka, Toshimasa Ishizaki and Toshihide Kimura
Funding Agency and Grant Number	Funding Agency Grant Number JSPS KAKENHI 19790636 JSPS KAKENHI 21790876 JSPS KAKENHI 23791039 JSPS KAKENHI 26461342 Institute for Molecular and Cellular Regulation, Gunma University, Takeda Science Foundation Novo Nordisk Pharma, Oita Broadcasting System Cultural Foundation Discretion of the President, Oita University
Corresponding Author	Toshihide Kimura, Associate Professor, Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan. t-kimura@oita-u.ac.jp
Key Words	Insulin; Exocytosis; Endocytosis; Rab27a; IQGAP1; Coronin 3; Glucose; Small GTPase
Core Tip	The small GTPase Rab27a is a member of the Rab family that is involved in membrane trafficking in pancreatic β-cells. GTP-bound Rab27a regulates insulin secretion at pre-exocytotic stages via its GTP-specific effectors such as Exophilin8/Slac2-c/MyRIP and Slp4/Granuphilin. Glucose stimulation causes insulin exocytosis. Glucose stimulation also converts Rab27a from its GTP- to its GDP-bound form. GDP-bound Rab27a interacts with GDP-specific effectors and controls endocytosis of the secretory membrane. Thus, Rab27a cycling between GTP- and GDP-bound forms synchronizes with the recycling of secretory membrane to re-use the membrane and keep the β-cell volume constant.
Publish Date	2015-04-20 09:13
Citation	Yamaoka M, Ishizaki T, Kimura T. Interplay between Rab27a effectors in pancreatic β-cells. World J Diabetes 2015; 6(3): 508-516
URL	http://www.wjgnet.com/1948-9358/full/v6/i3/508.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i3.508

Full Article (PDF)	WJD-6-508.pdf
Full Article (Word)	WJD-6-508.doc
Manuscript File	13497-Review.doc
Answering Reviewers	13497-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13497-Conflict-of-interest statement.pdf
Copyright License Agreement	13497-Copyright assignment.pdf
Peer-review Report	13497-Peer-review(s).pdf
Scientific Misconduct Check	13497-Scientific misconduct check.pdf
Scientific Editor Work List	13497-Scientific editor work list.pdf