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Articles Published Processes
3/20/2015 10:48:00 AM | Browse: 738 | Download: 727
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Received |
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2014-08-25 16:48 |
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Peer-Review Started |
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2014-08-25 17:44 |
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To Make the First Decision |
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2014-09-16 10:56 |
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Return for Revision |
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2014-09-19 11:28 |
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Revised |
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2014-10-02 12:57 |
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Second Decision |
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2014-11-12 14:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-11-19 10:48 |
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Articles in Press |
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2014-11-19 10:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-02-07 17:34 |
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Publish the Manuscript Online |
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2015-03-20 10:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Molecular mechanism of extrinsic factors affecting anti-aging of stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tzyy Yue Wong, Mairim Alexandra Solis, Ying-Hui Chen and Lynn Ling-Huei Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Council, Taiwan |
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| Corresponding Author |
Lynn Ling-Huei Huang, PhD, Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan. lynn@mail.ncku.edu.tw |
| Key Words |
Stem cells; Anti-aging; Quiescence; Micro-environment |
| Core Tip |
This review approaches anti-aging from aspect of stem cells. Stem cells may interact directly with their extracellular surroundings through caveolin-1, a lipid raft protein, to carry out and maintain stem cell functions. Mechanisms through hypoxia-inducible factor-1, glycolysis, and epigenetic regulators such as p300, protein inhibitors of activated Stats and H19 play crucial role in stem cell quiescence, and anti-aging regulations. Conversely, genomic instability such as DNA double-strand-breaks modulate cellular aging through the mammalian target of rapamycin pathway, which may lead to decreased lifespan. |
| Publish Date |
2015-03-20 10:47 |
| Citation |
Wong TY, Solis MA, Chen YH, Huang LLH. Molecular mechanism of extrinsic factors affecting anti-aging of stem cells. World J Stem Cells 2015; 7(2): 512-520 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i2/512.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i2.512 |
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